Hyponatremic hypertensive syndrome (HHS) in an 18-month old-child presenting as malignant hypertension: a case report
© Dixit et al; licensee BioMed Central Ltd. 2004
Received: 04 December 2003
Accepted: 27 April 2004
Published: 27 April 2004
The combination of hyponatremia and renovascular hypertension is called hyponatremic hypertensive syndrome (HHS). Malignant hypertension as a presentation has been reported in adults with HHS but is rare in children.
An eighteen month-old male presented with drowsiness, sudden onset status epilepticus and blood pressure of 210/160. The electrolytes on admission revealed sodium of 120 mEq/L and potassium of 2.1 mEq/L. The peripheral renin activity (PRA) was 172 ng/ml/min (normal 3–11 ng/ml/min) and serum aldosterone level was 91 ng/dl (normal 4 to 16 ng/dl). Patient underwent angioplasty with no success, followed by surgical correction. Two years since the diagnosis, the blood pressure is controlled with labetolol and amlodipine (at less than sixth of the pre-operative dosages). The PRA is 2.4 ng/ml/min and aldosterone 15.5 ng/dl. The child not only had three renal arteries on left but all of them were stenosed which to best of our knowledge has not been described.
As uncommon as HHS with malignant hypertension may be in adults it is under-reported in children and purpose of the case report is to raise its awareness.
The combination of hyponatremia and renovascular hypertension is called the hyponatremic hypertensive syndrome (HHS) [1–4]. The majority of patients reported have been elderly, asthenic females, and in most the underlying renal artery pathology was atherosclerosis . Patients with HHS present with central nervous system like headache, confusion, and may also have polydipsia and polyuria [1, 5, 6]. Malignant hypertension (HTN) as a presentation has been reported in adults with HHS but is rare in children beyond infancy with few reports [6–8].
With renal artery stenosis (RAS), renin secretion is increased resulting in high circulating angiotensin II (A-II) levels, leading to HTN and hyperaldosteronism resulting in pressure natriuresis . We report an 18-month old male presenting with seizures due to malignant HTN and subsequently found to have HHS. As uncommon HHS may be as in adults it maybe under-reported in children as well.
The patient remained on ventilator for a week. Initially rehabilitation potential was discussed but as BP was very gradually lowered by 10 mm of Hg per day, the toddler showed continued improvement in cortical function. After a week the patient was able to breathe spontaneously, nitroprusside was tapered off, and BP was controlled with intravenous (IV) labetolol and oral amlodipine was added later. The 2-D echo cardiogram showed severe concentric left ventricular hypertrophy (LVH). A nuclear renal scan done with 0.1 mg of IV enalaprilat resulted in decrease in BP from 150/110 to 90/60 mm of Hg and was accompanied by ST changes on EKG suggestive of cardiac ischemia. The result for RAS study was inconclusive as following drop in BP the radiotracer clearance from both kidneys completely ceased. Prior to IV enalaprilat the left kidney contributed 30% of overall function.
Eighteen months since the surgery and 2 years since the initial presentation he is on labetolol 25 mg twice a day (current weight 14 kg; 3.5 mg/kg/day) and amlodipine 1.25 mg/day (0.08 mg/kg/day). The dosages are approximately one-sixth of pre-operative dosages. His BP is currently in the range of 100–110/ 50–60. The PRA is 2.4 ng/ml/min, aldosterone is 15.5 ng/dl and the serum creatinine is 0.2 mg/dl. His LVH has regressed, MRI of brain has normalized, and his milestones have caught up to age appropriate levels. A nuclear renal scan done 18 months post-operatively shows that the left kidney now contributes 40% of the total function.
Pediatric Cases of HHS beyond Infancy
Number of cases
Dixit et al.
Left renal arterial (3) stenoses
Successful renal auto-graft
Dahlem et al.
Fibro-muscular dysplasia of left renal artery
Kaneko et al.
Left renal artery stenosis
Percutaneous transluminal angioplasty
Misiani et al.
Removal of the leiomyosarcoma; relapse
The renal ischemia leads to a sudden rise in arterial pressure that can induce a pressure natriuresis through the normal kidney, leading to volume depletion and further renin release from the ischemic kidney [5, 6, 11]. Potassium deficiency from hyperaldosteronism may further stimulate renin secretion and intensify the vicious circle. The hyponatremia itselfis presumed to result primarily from stimulation of thirst and antidiuretic hormone release [3, 9, 10]. Direct renal actions of A-II to retain water in excess of sodium may also contribute.
In some cases with RAS, an option is to remove the affected kidney as cure for HTN [12, 13]. We did consider the option but with 30% function in the affected left kidney every attempt was made to salvage it. The incidence of triple renal artery in one kidney is about 1% of population [14, 15]. The patient in our case report not only had three renal arteries on left but also all of them were stenosed which to best of our knowledge has not been described in an eighteen month old. The failure of angioplasty because of ~1 mm caliber of each of the vessels is not surprising.
The step-wise approach for investigation for RAS still remains initial renin estimation followed by a captopril scan for estimating the dependency of glomerular filtration rate (GFR) on A-II and, if needed, an angiogram combined with angioplasty [12, 16, 17]. In our patient A-II blockade during the first renal scan led to such profound decrease in BP that the child had cardiac ischemia due to hypotension. The BP of 90/60 at that time would be a normal BP for most children of his age but was relatively low for him. Continuation of A-II blockade for treatment of HTN would have led to loss of GFR mostly on the affected side. As our aim was to preserve the left kidney function A-II blockade was not a treatment option.
Our patient also suffered from failure to thrive, delayed milestones, and speech delay prior to the control of HTN. Two years later all of these symptoms have resolved. This underlies the importance of measurement of BP and early detection on HTN at any age.
In summary, in children the combination of hypereninemic malignant HTN with hyponatremia (HHS) does occur and ruling out renal ischemia due to RAS is strongly recommended.
hyponatremic hypertensive syndrome
renal artery stenosis
magnetic resonance imaging
magnetic resonance angiogram
peripheral renin activity
left ventricular hypertrophy
glomerular filtration rate
The authors wish to thank the Pediatric ICU staff and interventional radiology staff. Written consent was obtained from the parents of the child for the publication of the study.
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