Progressive neurological disease induced by tacrolimus in a renal transplant recipient: Case presentation
© Chegounchi et al; licensee BioMed Central Ltd. 2006
Received: 21 November 2005
Accepted: 31 March 2006
Published: 31 March 2006
Tacrolimus and cyclosporine, both calcineurin inhibitors, can cause neurological side effects. While mild symptoms such as tremor are well recognised, severe complications including seizures and encephalopathy are poorly documented following renal transplantation.
We report a 42 year old man who received a cadaver renal transplant. He received tacrolimus and prednisolone. The course was uneventful for 6 weeks when he became intermittently confused, with unsteady gait and slurred speech. Following a grand mal convulsion he was admitted. He had no focal neurological signs, cerebrospinal fluid was normal; electroencephalogram was consistent with temporal lobe partial epilepsy. The magnetic resonance imaging of brain showed widespread changes with multiple areas of low signal intensity in brain stem and cerebral hemispheres. He was readmitted 3 weeks later after further fits, despite anti-convulsant therapy. He was psychotic with visual hallucinations, and rapidly became obtunded. Although his tacrolimus blood concentration had been kept in the normal range, his symptoms improved dramatically when the tacrolimus was stopped.
Severe central nervous system toxicity from calcineurin inhibitors has been rarely reported in renal transplantation and we found only one report of tacrolimus-induced toxicity in an adult. We believe the condition is frequently undiagnosed. It is a very important diagnosis not to miss as the remedy is simple and failure may result in unnecessary brain biopsy, as well as irreversible injury.
Neurological complications of tacrolimus are usually mild (tremors, paraesthiae and myalgia), but can be severe with encephalopathy, seizures and coma. Severe complications have been more frequently reported following liver and lung than with renal transplantation [1–4], and typically occur with tacrolimus concentrations consistently above the therapeutic range of 15 ng/ml. We report the case of progressive neurological deterioration in a renal allograft recipient who suffered convulsions, intermittent confusion and finally mental obtundation. Severe central nervous system (CNS) toxicity from calcineurin inhibitors has been rarely reported in renal transplantation [2, 5] and we found only one report of tacrolimus in an adult. We believe the condition is frequently undiagnosed, and in our case the diagnosis was not considered for 2 months after onset of symptoms.
A 42 years old man of mixed race with an African father had originally presented with severe hypertension and renal failure. Renal biopsy showed severe vascular pathology but no primary glomerular disease. He underwent a cadaver renal transplant (111 mis-match) in July 2002 and received tacrolimus and prednisolone. The kidney functioned immediately. On day 8 (d8) with a plasma creatinine that had not fallen below 180 μmol/l and tacrolimus concentration consistently 15 ng/ml (target concentration 10–15 ng/ml), he had a renal biopsy that showed acute rejection (Banff IIa). He received intravenous methylprednisolone and Cellcept 500 mg bd was added. The creatinine fell to125 μmol/l.
He was readmitted three weeks later (d113) having had further fits. He was agitated, psychotic with visual hallucinations. No focal neurology was found and he rapidly became obtunded with a Glasgow coma score of 6–8/15. Repeat CT and MRI were unchanged. Lumbar puncture revealed high open pressure and raised protein 1.3 g/l but CSF analysis was otherwise normal. Repeat EEG was consisted with complex partial status epileptics with "frequent frontal notched theta activity". He was treated with antibiotic and antifungal agents and phenytoin infusion. There was no improvement in his condition and a diagnosis of tacrolimus-induced neurotoxicity was made (tacrolimus 10 ng/ml). Tacrolimus was switched to cyclosporine. Over the next few days he showed rapid and progressive improvement. He recovered fully and was discharge home. He has had no further seizure activity nor neurological symptoms since tacrolimus had been stopped. He continues to do well. A MRI scan performed in 2004 no longer showed the earlier lesions.
Severe calcineurin inhibitor-induced CNS toxicity is associated with a leucoencephalopathy . Neuro-radiological abnormalities are most commonly seen in the parietal-occipital region and appear as multifocal low attenuation of white matter on CT scan with corresponding hyper-intense lesions on MRI (T2-weighted). The changes may be very subtle[8, 9]. It has been suggested that the less frequent grey matter pathology can be visualised better using MRI with fluid-attenuated inversion recovery (FLAIR). These changes, however, are not specific. Sixteen patients with cyclosporine neurotoxicity investigated with MRI scans had findings identical to those reported in hypertensive encephalopathy and in 14 of 16 the symptoms improved after Bp became normal.
CSF analysis in calcineurin inhibitor-induced CNS toxicity is either normal or there may be a slight elevation of protein concentration as in our case. EEG may be non-specifically encephalopathic with diffuse slowing or may shown frank epileptic discharges as in the present case.
Cases generally occur early when blood levels of tacrolimus or cyclosporine are high, but can occur with normal levels. A review of 50 reported cases found a median time to onset of 28 days, with 82% of cases occurring within 90 days . Typically symptoms improved promptly when the dose was reduced or the drug stopped, but recovery can be incomplete [1, 14, 15]. The onset can be late, severe and irreversible [1, 6].
From the review of 50 cases by Singh and colleagues, seizures 74%, altered mental status 50%, and visual abnormalities 28% were the most frequently presenting features. Ten percent of the patients had fever with no documented source of infection.
Severe neurotoxicity in renal patients is usually multifactorial, with patients systemically unwell, uraemic and receiving combinations of potentially neurotoxic drugs. With cyclosporine leucoencephalopathy other contributing factors have been reported. Hypocholesterolaemia and hypomagnesaemia have been implicated, but were not present in our case; similarly, onset has often been associated with high blood pressure and fluid overload , which were also not features of this case. Initially it was assumed that the encephalopathy had an ischaemic basis, but more recently the similarity to mitochondrial encephalopathy has been described and investigated .
In our case the tacrolimus levels were often in the high normal range, particularly in the second month of his illness which was the fourth transplant month. We would recommend that tacrolimus levels are kept below 10 ng/ml after the second transplant month in straightforward transplants. Calcineurin inhibitor-induced CNS toxicity is a very important diagnosis not to miss as the remedy is simple and failure may result in unnecessary brain biopsy, as well as irreversible injury.
Written consent was obtained from the patient for publication of study.
- Fruhauf NR, Koeppen DS, Saner FH, Egelhof DT, Stavrou G, Nadalin S, Broelsch CE: Late onset of tacrolimus-related posterior leukoencephalopathy after living donor liver transplantation. Liver Transpl. 2003, 9: 983-985. 10.1053/jlts.2003.50181.View ArticlePubMedGoogle Scholar
- Singh N, Bonham A, Fukui M: Immunosuppressive-associated leukoencephalopathy in organ transplant recipients. Transplantation. 2000, 69: 467-472. 10.1097/00007890-200002270-00001.View ArticlePubMedGoogle Scholar
- Appignani BA, Bhadelia RA, Blacklow SC, Wang AK, Roland SF, Freeman RBJ: Neuroimaging findings in patients on immunosuppressive therapy: experience with tacrolimus toxicity. AJR Am J Roentgenol. 1996, 166: 683-688.View ArticlePubMedGoogle Scholar
- de Groen PC, Aksamit AJ, Rakela J, Forbes GS, Krom RA: Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol. N Engl J Med. 1987, 317: 861-866.View ArticlePubMedGoogle Scholar
- Parvex P, Pinsk M, Bell LE, O'Gorman AM, Patenaude YG, Gupta IR: Reversible encephalopathy associated with tacrolimus in pediatric renal transplants. Pediatr Nephrol. 2001, 16: 537-542. 10.1007/s004670100602.View ArticlePubMedGoogle Scholar
- Grimbert P, Azema C, Pastural M, Dhamane D, Remy P, Salomon L, Schortgen F, Baron C, Lang P: Tacrolimus (FK506)-induced severe and late encephalopathy in a renal transplant recipient. Nephrol Dial Transplant. 1999, 14: 2489-2491. 10.1093/ndt/14.10.2489.View ArticlePubMedGoogle Scholar
- Serkova NJ, Christians U, Benet LZ: Biochemical mechanisms of cyclosporine neurotoxicity. Mol Interv. 2004, 4: 97-107. 10.1124/mi.4.2.7.View ArticlePubMedGoogle Scholar
- Jansen O, Krieger D, Krieger S, Sartor K: Cortical hyperintensity on proton density-weighted images: An MR sign of cyclosporine-related encephalopathy. AJNR Am J Neuroradiol. 1996, 17: 337-344.PubMedGoogle Scholar
- Zimmer WE, Hourihane JM, Wang HZ, Schriber JR: The effect of human leukocyte antigen disparity on cyclosporine neurotoxicity after allogeneic bone marrow transplantation. AJNR Am J Neuroradiol. 1998, 19: 601-608.PubMedGoogle Scholar
- Casey SO, Sampaio RC, Michel E, Truwit CL: Posterior reversible encephalopathy syndrome: utility of fluid-attenuated inversion recovery MR imaging in the detection of cortical and subcortical lesions. AJNR Am J Neuroradiol. 2000, 21: 1199-1206.PubMedGoogle Scholar
- Schwartz RB, Bravo SM, Klufas RA, Hsu L, Barnes PD, Robson CD, Antin JH: Cyclosporine neurotoxicity and its relationship to hypertensive encephalopathy: CT and MR findings in 16 cases. AJR Am J Roentgenol. 1995, 165: 627-631.View ArticlePubMedGoogle Scholar
- Small SL, Fukui MB, Bramblett GT, Eidelman BH: Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506). Ann Neurol. 1996, 40: 575-580. 10.1002/ana.410400406.View ArticlePubMedGoogle Scholar
- Gleeson JG, duPlessis AJ, Barnes PD, Riviello JJJ: Cyclosporin A acute encephalopathy and seizure syndrome in childhood: clinical features and risk of seizure recurrence. J Child Neurol. 1998, 13: 336-344.View ArticlePubMedGoogle Scholar
- Torocsik HV, Curless RG, Post J, Tzakis AG, Pearse L: FK506-induced leukoencephalopathy in children with organ transplants. Neurology. 1999, 52: 1497-1500.View ArticlePubMedGoogle Scholar
- Misawa A, Takeuchi Y, Hibi S, Todo S, Imashuku S, Sawada T: FK506-induced intractable leukoencephalopathy following allogeneic bone marrow transplantation. Bone Marrow Transplant. 2000, 25: 331-334. 10.1038/sj.bmt.1702143.View ArticlePubMedGoogle Scholar
- Thompson CB, June CH, Sullivan KM, Thomas ED: Association between cyclosporin neurotoxicity and hypomagnesaemia. Lancet. 1984, 2: 1116-1120. 10.1016/S0140-6736(84)91556-3.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2369/7/7/prepub
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