Epidemiology and Health Outcomes

Section edited by Bernard Jaar

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  1. Research article

    Implementation of a pragmatic randomized trial of screening for chronic kidney disease to improve care among non-diabetic hypertensive veterans

    Whether screening for chronic kidney disease (CKD) can improve the care of persons at high risk for complications remains uncertain. We describe the design and early implementation experience of a pilot, clust...

    Carmen A. Peralta, Martin Frigaard, Anna D. Rubinsky, Leticia Rolon, Lowell Lo, Santhi Voora, Karen Seal, Delphine Tuot, Shirley Chao, Kimberly Lui, Phillip Chiao, Neil Powe and Michael Shlipak

    BMC Nephrology 2017 18:132

    Published on: 12 April 2017

  2. Study protocol

    A programme to spread eGFR graph surveillance for the early identification, support and treatment of people with progressive chronic kidney disease (ASSIST-CKD): protocol for the stepped wedge implementation and evaluation of an intervention to reduce late presentation for renal replacement therapy

    Patients who start renal replacement therapy (RRT) for End-Stage Kidney Disease (ESKD) without having had timely access to specialist renal services have poor outcomes. At one NHS Trust in England, a community...

    Hugh Gallagher, Shona Methven, Anna Casula, Nicola Thomas, Charles R. V. Tomson, Fergus J. Caskey, Tracey Rose, Stephen J. Walters, David Kennedy, Anne Dawnay, Martin Cassidy, Richard Fluck, Hugh C. Rayner and Michael Nation

    BMC Nephrology 2017 18:131

    Published on: 11 April 2017

  3. Research article

    Prevalence of chronic kidney disease associated with cardiac and vascular complications in hypertensive patients: a multicenter, nation-wide study in Thailand

    Hypertension and chronic kidney disease (CKD) are common conditions and both are major risk factors for cardiovascular events. The objectives were 1) to study the prevalence of CKD in hypertensive patients and...

    Rungroj Krittayaphong, Ram Rangsin, Bandit Thinkhamrop, Cameron Hurst, Suthee Rattanamongkolgul, Nintita Sripaiboonkij and Wipaporn Wangworatrakul

    BMC Nephrology 2017 18:115

    Published on: 3 April 2017

  4. Research article

    Coping with kidney disease – qualitative findings from the Empowering Patients on Choices for Renal Replacement Therapy (EPOCH-RRT) study

    The highly burdensome effects of kidney failure and its management impose many life-altering changes on patients. Better understanding of successful coping strategies will inform patients and help health care ...

    Lalita Subramanian, Martha Quinn, Junhui Zhao, Laurie Lachance, Jarcy Zee and Francesca Tentori

    BMC Nephrology 2017 18:119

    Published on: 3 April 2017

  5. Research article

    Kidney disease in Uganda: a community based study

    Chronic kidney disease (CKD) is a major cause of morbidity and mortality in Sub-Saharan Africa (SSA). The majority of studies on CKD in SSA have been conducted among HIV-infected populations and mainly from la...

    Robert Kalyesubula, Joaniter I. Nankabirwa, Isaac Ssinabulya, Trishul Siddharthan, James Kayima, Jane Nakibuuka, Robert A. Salata, Charles Mondo, Moses R. Kamya and Donald Hricik

    BMC Nephrology 2017 18:116

    Published on: 3 April 2017

  6. Research article

    Higher plasma transforming growth factor (TGF)-β is associated with kidney disease in older community dwelling adults

    TGF-β is induced in the vasculature with aging suggesting that high plasma TGF-β levels may be a risk factor for chronic kidney disease (CKD) in older adults.

    Tapan Mehta, Petra Buzkova, Jorge R. Kizer, Luc Djousse, Michel Chonchol, Kenneth J. Mukamal, Michael Shlipak, Joachim H. Ix and Diana Jalal

    BMC Nephrology 2017 18:98

    Published on: 21 March 2017

  7. Research article

    The cost-effectiveness of using chronic kidney disease risk scores to screen for early-stage chronic kidney disease

    Better treatment during early stages of chronic kidney disease (CKD) may slow progression to end-stage renal disease and decrease associated complications and medical costs. Achieving early treatment of CKD is...

    Benjamin O. Yarnoff, Thomas J. Hoerger, Siobhan K. Simpson, Alyssa Leib, Nilka R. Burrows, Sundar S. Shrestha and Meda E. Pavkov

    BMC Nephrology 2017 18:85

    Published on: 13 March 2017

  8. Research article

    Blood pressure and age-related GFR decline in the general population

    Hypertension is one of the most important causes of end-stage renal disease, but it is unclear whether elevated blood pressure (BP) also accelerates the gradual decline in the glomerular filtration rate (GFR) ...

    Bjørn O. Eriksen, Vidar T. N. Stefansson, Trond G. Jenssen, Ulla D. Mathisen, Jørgen Schei, Marit D. Solbu, Tom Wilsgaard and Toralf Melsom

    BMC Nephrology 2017 18:77

    Published on: 28 February 2017

  9. Research article

    Gaps and barriers in health-care provision for co-morbid diabetes and chronic kidney disease: a cross-sectional study

    Patients with diabetes and chronic kidney disease (CKD) are a complex subset of the growing number of patients with diabetes, due to multi-morbidity. Gaps between recommended and received care for diabetes and...

    C. Lo, H. Teede, G. Fulcher, M. Gallagher, P. G. Kerr, S. Ranasinha, G. Russell, R. Walker and S. Zoungas

    BMC Nephrology 2017 18:80

    Published on: 28 February 2017

  10. Research article

    The association of kidney function with repetitive breath-hold diving activities of female divers from Korea, Haenyeo

    Voluntary apnea during breath-hold diving (BHD) induces cardiovascular changes including bradycardia, reduced cardiac output, and arterial hypertension. Although the impacts of repetitive BHD on cardiovascular...

    Yun Jung Oh, Ji Yong Jung, Sung Soo Kim, Kyong-Suk Chae, Jiwon Rhu and Chungsik Lee

    BMC Nephrology 2017 18:75

    Published on: 23 February 2017

  11. Research article

    Vascular access conversion and patient outcome after hemodialysis initiation with a nonfunctional arteriovenous access: a prospective registry-based study

    Little is known about vascular access conversion and outcomes for patients starting hemodialysis with nonfunctional arteriovenous (AV) access. We assessed mortality risk associated with nonfunctional AV access...

    Natalia Alencar de Pinho, Raphael Coscas, Marie Metzger, Michel Labeeuw, Carole Ayav, Christian Jacquelinet, Ziad A Massy and Bénédicte Stengel

    BMC Nephrology 2017 18:74

    Published on: 22 February 2017

  12. Research article

    Incidence, timing and outcome of AKI in critically ill patients varies with the definition used and the addition of urine output criteria

    Acute kidney injury (AKI) is a serious complication of critical illness with both attributed morbidity and mortality at short-term and long-term. The incidence of AKI reported in critically ill patients varies...

    J. Koeze, F. Keus, W. Dieperink, I. C. C. van der Horst, J. G. Zijlstra and M. van Meurs

    BMC Nephrology 2017 18:70

    Published on: 20 February 2017

  13. Research article

    Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis

    Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today ...

    M. P. Cristelli, F. Cofán, N. Rico, J. C. Trullàs, C. Manzardo, F. Agüero, J. L. Bedini, A. Moreno, F. Oppenheimer and J. M. Miro

    BMC Nephrology 2017 18:58

    Published on: 10 February 2017

  14. Research article

    Low renal replacement therapy incidence among slowly progressing elderly chronic kidney disease patients referred to nephrology care: an observational study

    Elderly patients with advanced chronic kidney disease (CKD) have a high risk of death before reaching end-stage kidney disease. In order to allocate resources, such as advanced care nephrology where it is most...

    Ulrika Hahn Lundström, Alessandro Gasparini, Rino Bellocco, Abdul Rashid Qureshi, Juan-Jesus Carrero and Marie Evans

    BMC Nephrology 2017 18:59

    Published on: 10 February 2017

  15. Research article

    Association of estimated glomerular filtration rate and urine albumin-to-creatinine ratio with incidence of cardiovascular diseases and mortality in chinese patients with type 2 diabetes mellitus – a population-based retrospective cohort study

    Estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) are renal markers associated with risks of cardiovascular diseases (CVD) and all-cause mortality in diabetic patients. T...

    Colman Siu Cheung Fung, Eric Yuk Fai Wan, Anca Ka Chun Chan and Cindy Lo Kuen Lam

    BMC Nephrology 2017 18:47

    Published on: 2 February 2017

  16. Research article

    Medication adherence in randomized controlled trials evaluating cardiovascular or mortality outcomes in dialysis patients: A systematic review

    Medication non-adherence is common among renal dialysis patients. High degrees of non-adherence in randomized controlled trials (RCTs) can lead to failure to detect a true treatment effect. Cardio-protective p...

    Karumathil M Murali, Judy Mullan, Jenny H. C. Chen, Steven Roodenrys and Maureen Lonergan

    BMC Nephrology 2017 18:42

    Published on: 31 January 2017

  17. Research article

    Costs of care at the end of life among elderly patients with chronic kidney disease: patterns and predictors in a nationwide cohort study

    Despite the urgent need for evidence to guide the end-of-life (EOL) care for patients with chronic kidney disease (CKD), we have limited knowledge of the costs and intensity of EOL care in this population. The...

    Bradley Chen, Victoria Y. Fan, Yiing-Jenq Chou and Chin-Chi Kuo

    BMC Nephrology 2017 18:36

    Published on: 26 January 2017

  18. Research article

    Genetic risk score and risk of stage 3 chronic kidney disease

    We developed a genetic risk score (GRS) and examined whether the GRS may predict incident stage 3 chronic kidney disease (CKD) independent of common clinical risk factors.

    Jiantao Ma, Qiong Yang, Shih-Jen Hwang, Caroline S. Fox and Audrey Y. Chu

    BMC Nephrology 2017 18:32

    Published on: 19 January 2017

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