Epidemiology and Health Outcomes

Section edited by Bernard Jaar

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  1. Research article

    The effect of disease severity markers on quality of life in autosomal dominant polycystic kidney disease: a systematic review, meta-analysis and meta-regression

    Little is known about determinants of quality of life (QoL) in autosomal dominant polycystic kidney disease (ADPKD). Recent studies suggest that QoL in ADPKD is determined by more factors than mere renal funct...

    Myrte K. Neijenhuis, Wietske Kievit, Ronald D. Perrone, Jeff A. Sloan, Patricia Erwin, Mohammad Hassan Murad, Tom J. G. Gevers, Marie C. Hogan and Joost P. H. Drenth

    BMC Nephrology 2017 18:169

    Published on: 25 May 2017

  2. Research article

    Periodontitis and early mortality among adults treated with hemodialysis: a multinational propensity-matched cohort study

    Periodontitis is associated with cardiovascular mortality in the general population and adults with chronic diseases. However, it is unclear whether periodontitis predicts survival in the setting of kidney fai...

    Marinella Ruospo, Suetonia C Palmer, Germaine Wong, Jonathan C Craig, Massimo Petruzzi, Michele De Benedittis, Pauline Ford, David W Johnson, Marcello Tonelli, Patrizia Natale, Valeria Saglimbene, Fabio Pellegrini, Eduardo Celia, Ruben Gelfman, Miguel R Leal, Marietta Torok…

    BMC Nephrology 2017 18:166

    Published on: 22 May 2017

  3. Research article

    Increased resistance of gram-negative urinary pathogens after kidney transplantation

    Urinary tract infection is the most common complication after kidney transplantation. It can cause severe sepsis and transplant loss. Emergence of drug resistance among gram-negative urinary pathogens is the c...

    Johannes Korth, Julia Kukalla, Peter-Michael Rath, Sebastian Dolff, Marco Krull, Hana Guberina, Anja Bienholz, Benjamin Wilde, Stefan Becker, Birgit Ross, Olympia Evdoxia Anastasiou, Andreas Kribben and Oliver Witzke

    BMC Nephrology 2017 18:164

    Published on: 19 May 2017

  4. Research article

    Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study

    Whether metformin precipitates lactic acidosis in patients with chronic kidney disease (CKD) remains under debate. We examined whether metformin use was associated with an increased risk of acute kidney injury...

    Samira Bell, Bassam Farran, Stuart McGurnaghan, Rory J. McCrimmon, Graham P Leese, John R Petrie, Paul McKeigue, Naveed Sattar, Sarah Wild, John McKnight, Robert Lindsay, Helen M. Colhoun and Helen Looker

    BMC Nephrology 2017 18:163

    Published on: 19 May 2017

  5. Research article

    The association between urbanization and reduced renal function: findings from the China Health and Nutrition Survey

    While chronic kidney disease (CKD) is a growing public health concern in low- and middle-income countries, such as China, few studies have investigated the association between urbanization and the occurrence o...

    Yosuke Inoue, Annie Green Howard, Amanda L. Thompson, Michelle A. Mendez, Amy H. Herring and Penny Gordon-Larsen

    BMC Nephrology 2017 18:160

    Published on: 15 May 2017

  6. Research article

    Risk factors for developing acute kidney injury in older people with diabetes and community-acquired pneumonia: a population-based UK cohort study

    Acute kidney injury (AKI) is being increasingly recognised in ageing populations. There are a paucity of data about AKI risk factors among older individuals with diabetes and infections, who are at particularl...

    Anu Jain, Helen I. McDonald, Dorothea Nitsch, Laurie Tomlinson and Sara L. Thomas

    BMC Nephrology 2017 18:142

    Published on: 1 May 2017

  7. Research article

    Effect on non-vascular outcomes of lowering LDL cholesterol in patients with chronic kidney disease: results from the Study of Heart and Renal Protection

    Reducing LDL cholesterol (LDL-C) with statin-based therapy reduces the risk of major atherosclerotic events among patients with chronic kidney disease (CKD), with no evidence of an excess risk of cancer or dea...

    C. Reith, N. Staplin, W. G. Herrington, W. Stevens, J. Emberson, R. Haynes, M. Mafham, J. Armitage, A. Cass, J. C. Craig, L. Jiang, T. Pedersen, C. Baigent and M. J. Landray

    BMC Nephrology 2017 18:147

    Published on: 1 May 2017

  8. Research article

    Statin use and hip fractures in U.S. kidney transplant recipients

    Basic and translational research supports beneficial effects of statins on bone metabolism. Clinical studies suggest that statin use may reduce the risk of hip fractures in the general population. Whether stat...

    Chandan Vangala, Colin R. Lenihan, Maria E. Montez-Rath, Sumi Sukumaran Nair, Sankar D. Navaneethan, Venkat Ramanathan and Wolfgang C. Winkelmayer

    BMC Nephrology 2017 18:145

    Published on: 1 May 2017

  9. Research article

    Implementation of a pragmatic randomized trial of screening for chronic kidney disease to improve care among non-diabetic hypertensive veterans

    Whether screening for chronic kidney disease (CKD) can improve the care of persons at high risk for complications remains uncertain. We describe the design and early implementation experience of a pilot, clust...

    Carmen A. Peralta, Martin Frigaard, Anna D. Rubinsky, Leticia Rolon, Lowell Lo, Santhi Voora, Karen Seal, Delphine Tuot, Shirley Chao, Kimberly Lui, Phillip Chiao, Neil Powe and Michael Shlipak

    BMC Nephrology 2017 18:132

    Published on: 12 April 2017

  10. Study protocol

    A programme to spread eGFR graph surveillance for the early identification, support and treatment of people with progressive chronic kidney disease (ASSIST-CKD): protocol for the stepped wedge implementation and evaluation of an intervention to reduce late presentation for renal replacement therapy

    Patients who start renal replacement therapy (RRT) for End-Stage Kidney Disease (ESKD) without having had timely access to specialist renal services have poor outcomes. At one NHS Trust in England, a community...

    Hugh Gallagher, Shona Methven, Anna Casula, Nicola Thomas, Charles R. V. Tomson, Fergus J. Caskey, Tracey Rose, Stephen J. Walters, David Kennedy, Anne Dawnay, Martin Cassidy, Richard Fluck, Hugh C. Rayner and Michael Nation

    BMC Nephrology 2017 18:131

    Published on: 11 April 2017

  11. Research article

    Prevalence of chronic kidney disease associated with cardiac and vascular complications in hypertensive patients: a multicenter, nation-wide study in Thailand

    Hypertension and chronic kidney disease (CKD) are common conditions and both are major risk factors for cardiovascular events. The objectives were 1) to study the prevalence of CKD in hypertensive patients and...

    Rungroj Krittayaphong, Ram Rangsin, Bandit Thinkhamrop, Cameron Hurst, Suthee Rattanamongkolgul, Nintita Sripaiboonkij and Wipaporn Wangworatrakul

    BMC Nephrology 2017 18:115

    Published on: 3 April 2017

  12. Research article

    Coping with kidney disease – qualitative findings from the Empowering Patients on Choices for Renal Replacement Therapy (EPOCH-RRT) study

    The highly burdensome effects of kidney failure and its management impose many life-altering changes on patients. Better understanding of successful coping strategies will inform patients and help health care ...

    Lalita Subramanian, Martha Quinn, Junhui Zhao, Laurie Lachance, Jarcy Zee and Francesca Tentori

    BMC Nephrology 2017 18:119

    Published on: 3 April 2017

  13. Research article

    Kidney disease in Uganda: a community based study

    Chronic kidney disease (CKD) is a major cause of morbidity and mortality in Sub-Saharan Africa (SSA). The majority of studies on CKD in SSA have been conducted among HIV-infected populations and mainly from la...

    Robert Kalyesubula, Joaniter I. Nankabirwa, Isaac Ssinabulya, Trishul Siddharthan, James Kayima, Jane Nakibuuka, Robert A. Salata, Charles Mondo, Moses R. Kamya and Donald Hricik

    BMC Nephrology 2017 18:116

    Published on: 3 April 2017

  14. Research article

    Higher plasma transforming growth factor (TGF)-β is associated with kidney disease in older community dwelling adults

    TGF-β is induced in the vasculature with aging suggesting that high plasma TGF-β levels may be a risk factor for chronic kidney disease (CKD) in older adults.

    Tapan Mehta, Petra Buzkova, Jorge R. Kizer, Luc Djousse, Michel Chonchol, Kenneth J. Mukamal, Michael Shlipak, Joachim H. Ix and Diana Jalal

    BMC Nephrology 2017 18:98

    Published on: 21 March 2017

  15. Research article

    The cost-effectiveness of using chronic kidney disease risk scores to screen for early-stage chronic kidney disease

    Better treatment during early stages of chronic kidney disease (CKD) may slow progression to end-stage renal disease and decrease associated complications and medical costs. Achieving early treatment of CKD is...

    Benjamin O. Yarnoff, Thomas J. Hoerger, Siobhan K. Simpson, Alyssa Leib, Nilka R. Burrows, Sundar S. Shrestha and Meda E. Pavkov

    BMC Nephrology 2017 18:85

    Published on: 13 March 2017

  16. Research article

    Blood pressure and age-related GFR decline in the general population

    Hypertension is one of the most important causes of end-stage renal disease, but it is unclear whether elevated blood pressure (BP) also accelerates the gradual decline in the glomerular filtration rate (GFR) ...

    Bjørn O. Eriksen, Vidar T. N. Stefansson, Trond G. Jenssen, Ulla D. Mathisen, Jørgen Schei, Marit D. Solbu, Tom Wilsgaard and Toralf Melsom

    BMC Nephrology 2017 18:77

    Published on: 28 February 2017

  17. Research article

    Gaps and barriers in health-care provision for co-morbid diabetes and chronic kidney disease: a cross-sectional study

    Patients with diabetes and chronic kidney disease (CKD) are a complex subset of the growing number of patients with diabetes, due to multi-morbidity. Gaps between recommended and received care for diabetes and...

    C. Lo, H. Teede, G. Fulcher, M. Gallagher, P. G. Kerr, S. Ranasinha, G. Russell, R. Walker and S. Zoungas

    BMC Nephrology 2017 18:80

    Published on: 28 February 2017

  18. Research article

    The association of kidney function with repetitive breath-hold diving activities of female divers from Korea, Haenyeo

    Voluntary apnea during breath-hold diving (BHD) induces cardiovascular changes including bradycardia, reduced cardiac output, and arterial hypertension. Although the impacts of repetitive BHD on cardiovascular...

    Yun Jung Oh, Ji Yong Jung, Sung Soo Kim, Kyong-Suk Chae, Jiwon Rhu and Chungsik Lee

    BMC Nephrology 2017 18:75

    Published on: 23 February 2017

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