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  1. Case report

    Steroid-resistant nephrotic syndrome as the initial presentation of nail-patella syndrome: a case of a de novo LMX1B mutation

    Nail-patella syndrome (NPS) is an autosomal dominant disorder caused by mutations in the LMX1B gene and is characterized by nail dysplasia, skeletal abnormalities, and nephropathy. We herein report a case of s...

    Tomohiro Nakata, Ryo Ishida, Yuu Mihara, Atsuko Fujii, Yoshimoto Inoue, Tetsuro Kusaba, Tsuyoshi Isojima, Yutaka Harita, Chiaki Kanda, Sachiko Kitanaka and Keiichi Tamagaki

    BMC Nephrology 2017 18:100

    Published on: 23 March 2017

  2. Research article

    The risk of diabetic renal function impairment in the first decade after diagnosed of diabetes mellitus is correlated with high variability of visit-to-visit systolic and diastolic blood pressure: a case control study

    The variability of visit-to-visit (VVV) in systolic blood pressure (SBP) and diastolic blood pressure (DBP) is proved as a predictor of renal function deterioration in patients with non-diabetic chronic kidney...

    Chi-Hsiao Yeh, Hsiu-Chin Yu, Tzu-Yen Huang, Pin-Fu Huang, Yao-Chang Wang, Tzu-Ping Chen and Shun-Ying Yin

    BMC Nephrology 2017 18:99

    Published on: 22 March 2017

  3. Research article

    Higher plasma transforming growth factor (TGF)-β is associated with kidney disease in older community dwelling adults

    TGF-β is induced in the vasculature with aging suggesting that high plasma TGF-β levels may be a risk factor for chronic kidney disease (CKD) in older adults.

    Tapan Mehta, Petra Buzkova, Jorge R. Kizer, Luc Djousse, Michel Chonchol, Kenneth J. Mukamal, Michael Shlipak, Joachim H. Ix and Diana Jalal

    BMC Nephrology 2017 18:98

    Published on: 21 March 2017

  4. Case report

    Case report - atypical hemolytic uremic syndrome triggered by influenza B

    Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulati...

    Robin Kobbe, Raphael Schild, Martin Christner, Jun Oh, Sebastian Loos and Markus J. Kemper

    BMC Nephrology 2017 18:96

    Published on: 20 March 2017

  5. Research article

    Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy

    Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. T...

    In Mi Han, Chang-Yun Yoon, Dong Ho Shin, Youn Kyung Kee, Seung Gyu Han, Young Eun Kwon, Kyoung Sook Park, Mi Jung Lee, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang and Tae-Hyun Yoo

    BMC Nephrology 2017 18:94

    Published on: 20 March 2017

  6. Research article

    Cardiovascular risk is similar in patients with glomerulonephritis compared to other types of chronic kidney disease: a matched cohort study

    Patients with chronic kidney disease (CKD) due to glomerulonephritis (GN) are thought to be at high risk for cardiovascular disease (CVD). However, no study has examined whether GN directly contributes to CV r...

    Holly L. Hutton, Adeera Levin, Jagbir Gill, Ognjenka Djurdjev, Mila Tang and Sean J. Barbour

    BMC Nephrology 2017 18:95

    Published on: 20 March 2017

  7. Research article

    Renal effects of metallothionein induction by zinc in vitro and in vivo

    Metallothionein (MTT) is an endogenous antioxidant that can be induced by both zinc (Zn) and ischemia. In kidneys, increased MTT expression exerts a putative protective role in diabetes and hypoxia. Our goal w...

    Moritz Schanz, Lea Schaaf, Juergen Dippon, Dagmar Biegger, Peter Fritz, Mark Dominik Alscher and Martin Kimmel

    BMC Nephrology 2017 18:91

    Published on: 16 March 2017

  8. Research article

    Clinical and laboratory parameters associated with acute kidney injury in patients with snakebite envenomation: a prospective observational study from Myanmar

    Snakebite-related acute kidney injury (AKI) is a common community-acquired AKI in tropical countries leading to death and disability. The aims of this study were to (1) determine the occurrence of snakebite-re...

    Kyi-Phyu Aye, Vipa Thanachartwet, Chit Soe, Varunee Desakorn, Khin-Thida Thwin, Supat Chamnanchanunt, Duangjai Sahassananda, Thanom Supaporn and Visith Sitprija

    BMC Nephrology 2017 18:92

    Published on: 16 March 2017

  9. Research article

    Effects of stroke on changes in heart rate variability during hemodialysis

    Stroke and low heart rate variability (HRV) are both associated with an unfavorable prognosis in hemodialysis patients. The relationship between stroke and changes in HRV during hemodialysis remains unclear.

    Jiun-Chi Huang, Chien-Fu Chen, Chia-Chu Chang, Szu-Chia Chen, Ming-Chia Hsieh, Yao-Peng Hsieh and Hung-Chun Chen

    BMC Nephrology 2017 18:90

    Published on: 16 March 2017

  10. Research article

    Poor predictability of QuantiFERON-TB assay in recipients and donors for tuberculosis development after kidney transplantation in an intermediate-TB-burden country

    Tuberculosis (TB) is a common opportunistic infection after kidney transplantation (KT). The QuantiFERON-TB-Gold In-Tube test (QFT) is widely used for assessing latent TB; however, it is currently unclear whet...

    Enkthuya Jambaldorj, Miyeun Han, Jong Cheol Jeong, Tai Yeon Koo, Sang Il Min, Eun Young Song, Jongwon Ha, Curie Ahn and Jaeseok Yang

    BMC Nephrology 2017 18:88

    Published on: 14 March 2017

  11. Research article

    Significance of clinical and morphological prognostic risk factors in IgA nephropathy: follow-up study of comparison patient groups with and without renoprotection

    IgA nephropathy (IgAN) is the most frequent glomerulonephritis in many countries including Estonia. There is no specific treatment for IgAN but renoprotection is indicated when proteinuria is >1 g/day. We aime...

    Živile Riispere, Anne Kuudeberg, Elviira Seppet, Kristin Sepp, Madis Ilmoja, Merike Luman, Külli Kõlvald, Asta Auerbach and Mai Ots-Rosenberg

    BMC Nephrology 2017 18:89

    Published on: 14 March 2017

  12. Research article

    Effect of tolvaptan on renal water and sodium excretion and blood pressure during nitric oxide inhibition: a dose-response study in healthy subjects

    Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron’s principal cells. In a dose-response study, we m...

    Safa Al Therwani, Jeppe Bakkestrøm Rosenbæk, Frank Holden Mose, Jesper Nørgaard Bech and Erling Bjerregaard Pedersen

    BMC Nephrology 2017 18:86

    Published on: 13 March 2017

  13. Research article

    The cost-effectiveness of using chronic kidney disease risk scores to screen for early-stage chronic kidney disease

    Better treatment during early stages of chronic kidney disease (CKD) may slow progression to end-stage renal disease and decrease associated complications and medical costs. Achieving early treatment of CKD is...

    Benjamin O. Yarnoff, Thomas J. Hoerger, Siobhan K. Simpson, Alyssa Leib, Nilka R. Burrows, Sundar S. Shrestha and Meda E. Pavkov

    BMC Nephrology 2017 18:85

    Published on: 13 March 2017

  14. Research article

    Abdominal aortic calcification on a plain X-ray and the relation with significant coronary artery disease in asymptomatic chronic dialysis patients

    Coronary artery disease (CAD) is common in asymptomatic chronic dialysis patients and plays an important role in their poor survival. Early identification of these high-risk patients could improve treatment an...

    M. K. de Bie, M. S. Buiten, J. I. Rotmans, M. Hogenbirk, M. J. Schalij, T. J. Rabelink and J. W. Jukema

    BMC Nephrology 2017 18:82

    Published on: 2 March 2017

  15. Research article

    Effectiveness of Integrated Care on Delaying Progression of stage 3-4 Chronic Kidney Disease in Rural Communities of Thailand (ESCORT study): a cluster randomized controlled trial

    In developing countries, renal specialists are scarce and physician-to-patient contact time is limited. While conventional hospital-based, physician-oriented approach has been the main focus of chronic kidney ...

    Teerayuth Jiamjariyapon, Atiporn Ingsathit, Krit Pongpirul, Kotcharat Vipattawat, Suphattra Kanchanakorn, Akhathai Saetie, Duangjit Kanistanon, Patimaporn Wongprompitak, Vinai Leesmidt, Watcharapong Watcharasaksilp, Wei Wang, Anil K. Chandraker and Kriang Tungsanga

    BMC Nephrology 2017 18:83

    Published on: 2 March 2017

  16. Technical advance

    A new prescription model for regional citrate anticoagulation in therapeutic plasma exchanges

    Regional citrate anticoagulation (RCA) is proposed for various extracorporeal purification techniques to overcome the risk of bleeding that might result from systemic anticoagulation. Yet, no individualized tr...

    Sébastien Kissling, Cécile Legallais, Menno Pruijm, Daniel Teta, Bruno Vogt, Michel Burnier, Eric Rondeau and Christophe Ridel

    BMC Nephrology 2017 18:81

    Published on: 1 March 2017

    The Erratum to this article has been published in BMC Nephrology 2017 18:84

  17. Research article

    Relationship between history of coronary heart disease at dialysis initiation and onset of events associated with heart disease: a propensity-matched analysis of a prospective cohort study

    Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease (CVD) events, and a number of reports have shown a relationship between CKD and CVD in pre-dialysis or maintenance dialysis...

    Daijo Inaguma, Shigehisa Koide, Kazuo Takahashi, Hiroki Hayashi, Midori Hasegawa and Yukio Yuzawa

    BMC Nephrology 2017 18:79

    Published on: 28 February 2017

  18. Research article

    Blood pressure and age-related GFR decline in the general population

    Hypertension is one of the most important causes of end-stage renal disease, but it is unclear whether elevated blood pressure (BP) also accelerates the gradual decline in the glomerular filtration rate (GFR) ...

    Bjørn O. Eriksen, Vidar T. N. Stefansson, Trond G. Jenssen, Ulla D. Mathisen, Jørgen Schei, Marit D. Solbu, Tom Wilsgaard and Toralf Melsom

    BMC Nephrology 2017 18:77

    Published on: 28 February 2017

  19. Research article

    Gaps and barriers in health-care provision for co-morbid diabetes and chronic kidney disease: a cross-sectional study

    Patients with diabetes and chronic kidney disease (CKD) are a complex subset of the growing number of patients with diabetes, due to multi-morbidity. Gaps between recommended and received care for diabetes and...

    C. Lo, H. Teede, G. Fulcher, M. Gallagher, P. G. Kerr, S. Ranasinha, G. Russell, R. Walker and S. Zoungas

    BMC Nephrology 2017 18:80

    Published on: 28 February 2017

  20. Research article

    Early versus late initiation of renal replacement therapy in patients with acute kidney injury-a systematic review & meta-analysis of randomized controlled trials

    Acute kidney injury (AKI) is a common complication in the critically ill patients and associated with a substantial morbidity and mortality. Severe AKI may be associated with up to 60% hospital mortality. Over...

    Girish Chandra Bhatt and Rashmi Ranjan Das

    BMC Nephrology 2017 18:78

    Published on: 28 February 2017

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