TY - JOUR AU - Thomas, Merlin C. AU - Moran, John AU - Mathew, Timothy H. AU - Russ, Graeme R. AU - Mohan Rao, M. PY - 2000 DA - 2000/10/04 TI - Early peri-operative hyperglycaemia and renal allograft rejection in patients withoutdiabetes JO - BMC Nephrology SP - 1 VL - 1 IS - 1 AB - Patients with diabetes have an increased risk for allograft rejection, possibly related to peri-operative hyperglycaemia. Hyperglycaemia is also common following transplantation in patients without diabetes. We hypothesise that exposure of allograft tissue to hyperglycaemia could influence the risk for rejection in any patient with high sugars. To investigate the relationship of peri-operative glucose control to acute rejection in renal transplant patients without diabetes, all patients receiving their first cadaveric graft in a single center were surveyed and patients without diabetes receiving cyclosporin-based immunosuppression were reviewed (n = 230). Records of the plasma blood glucose concentration following surgery and transplant variables pertaining to allograft rejection were obtained. All variables suggestive of association were entered into multivariate logistic regression analysis, their significance analysed and modeled. SN - 1471-2369 UR - https://doi.org/10.1186/1471-2369-1-1 DO - 10.1186/1471-2369-1-1 ID - Thomas2000 ER -