Offspring of parents with Balkan Endemic Nephropathy have higher C-reactive protein levels suggestive of inflammatory processes: a longitudinal study

Table 3 Effect of being an offspring of a BEN patient on the level of C-reactive protein^#

	Repeated measurement-analysis: 200 participants, 349 observations
	Model comparing offspring BEN status		Model comparing parental history of BEN
	Parameter Estimate^¥	p-value (t-test)	Parameter Estimate^†	p-value (t-test)
Offspring of BEN patient vs offspring of control patient	0.102	0.043	-
Parental history of BEN:
both	-		0.189	0.01
mother	-		0.146	0.03
father	-		0.013	0.85
none	-		Reference
Age (years)	0.012	< 0.0001	0.01	0.0005
Gender (female)	0.073	0.178	0.06	0.26
Body-mass index	0.038	< 0.0001	0.038	< 0.0001
Smoking in the last 12 months	0.157	0.007	0.153	0.009

^# CRP (mg/dL) is log 10 transformed
^¥ Statistically controlled for ex-smoking, history of pyelonephritis, cystitis, other kidney diseases
† Statistically controlled for ex-smoking, history of cystitis, administration of steroid hormones

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