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Table 1 Transcripts represented by SAGE tags enriched 30 fold or more in glomeruli

From: A human glomerular SAGE transcriptome database

Symbol Gene Name NlaIII long Tag Sau3A Tag G:TPM
Sau3A
G:TPM
NlaIII
P:TPM
NlaIII
K:TPM
NlaIII
Ratio
G: P
Ratio
G: K
Link
SAGE Genie
Link
Ref
NPHS2 Nephrosis 2, idiopathic, steroid-resistant (podocin) TTTCCGTGACTCATCTA CCTCACTGAA 1,534 2,287 0 48 Infinity 48 NPHS2 Ref:NPHS2
SOST Sclerosteosis ACATATGAAAGCCTGCA TCGAGGAGAC 158 82 0 0 Infinity   SOST  
MME Membrane metallo-endopeptidase CTGCAGTGTTCGAGTGG TATAAAGCGA 271 102 0 0 4446   MME Ref:MME
CLIC5 Chloride intracellular channel 5 AATCTGAACCAATTACC CAGTCATCTG 1,038 3,593 5 24 719 150 CLIC5 Ref:CLIC5
NPHS1 Nephrosis 1, congenital, Finnish type (nephrin) TAAACATAAGTATGCTC    1,041 2 0 549   NPHS1 Ref:NPHS1
TCF21 Transcription factor 21 CGAGTGCTGAGCAAGGC ATAGGATAGC 451 817 2 0 514   TCF21 Ref:TCF21
CDKN1C Cyclin-dependent kinase inhibitor 1C (p57, Kip2) CCGCTGCGGGGCCCTGG AGCGCCTGAG 383 490 1 0 506   CDKN1C Ref:CDKN1C
DDN Dendrin TGAACTTGGCCACATCA    306 1 0 373   DDN Ref:DDN
THYMU2010816 CDNA FLJ36413 fis, clone THYMU2010816 TATCACTGGGGAGGGAA ATTAGTCAAT 203 449 2 0 285   THYMU2010816  
FLJ22271 CDNA: FLJ22271 fis, clone HRC03191 GCTTTGTCGCAACGCTC    82 0 0 263   FLJ22271  
PTPRO Protein tyrosine phosphatase, receptor type, O GATATACAACAGAAAAC AACTGTGTAA 226 755 4 0 215   PTPRO Ref:PTPRO
FGF1 Fibroblast growth factor 1 (acidic) TAAAGGCCTTTAATAAG TTCTTAGAAG 474 102 0 24 210 4 FGF1 Ref:FGF1
PTHR1 Parathyroid hormone receptor 1 TGACCAGGCGCTGGGGG    1,143 8 96 141 12 PTHR1 Ref:PTHR1
CLDN5 Claudin 5 GTAGGCGGCTGCCTCTT    82 1 0 127   CLDN5  
LRRC2 Leucine rich repeat containing 2 GGACTGCACTCCAGCCT    82 1 0 108   LRRC2  
AL049990 MRNA; cDNA DKFZp564G112 (from clone DKFZp564G112) ACTTGGAAATAAACAAA    143 1 0 105   AL049990  
HTRA1 HtrA serine peptidase 1 ACCGACAGGCCAAAGGA CGCAGGCAGA 1,398 143 1 0 105   HTRA1  
FAM65A Family with sequence similarity 65, member A GCTGCTGTCAGCACCCA AGGCTGTTGT 316 204 2 0 99   FAM65A  
SEMA3G Semaphorin 3G ACTGCCCCTGAGCTCTG    674 7 24 94 28 SEMA3G  
SPOCK1 Sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 AGAATACCTTAATACTG TTTAATACTT 226 122 1 0 92   SPOCK1  
CRB2 Crumbs homolog 2 (Drosophila) TGCAGCAGTGGCAGCCT    367 4 0 89   CRB2  
ENPEP Glutamyl aminopeptidase (aminopeptidase A) GCCTGGAATTGGATACA ATATGAATTA 632 143 2 96 79 1 ENPEP Ref:ENPEP
SLC45A1 Solute carrier family 45, member 1 GGCGTGGACATCTCTCT    143 2 0 77   SLC45A1  
TNNT2 Troponin T type 2 (cardiac) ATGCATTTTGGGGGTTA TGCTCCTCGC 338 184 2 24 76 8 TNNT2  
CD34 CD34 molecule GGACCAGGTCTTGGAGC    102 1 24 75 4 CD34 Ref;CD34
EFNB1 Ephrin-B1 AGGGAAGAGGAAAGTGC    102 2 0 68   EFNB1 Ref:EFNB1
IL1RL1 Interleukin 1 receptor-like 1 (ST2 Protein) AGGGCAGGGACATCATC TTTGTAGACT 158 82 1 0 64   IL1RL1  
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N- TGATGCCCTTGAACACC    286 5 0 63   ST6GALNAC3 Ref:ST6GALNAC3
  acetylgalactosaminide alpha-2,6-sialyltransferase 3           
NTNG1 Netrin G1 TGTAACAGCCCCCTCTA    102 2 0 63   NTNG1  
SPOCK2 Sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 CATAAAGGAAATCAAAT TGGTAGGTTG 248 1,123 18 0 61   SPOCK2  
ABLIM2 Actin binding LIM protein family, member 2 ACACGCCAAGTCCCGTT    122 2 0 60   ABLIM2 Ref:ABLIM2
MGC16291 Hypothetical protein MGC16291 TGGGTCAAACTCTGAAA    122 2 24 58 5 MGC16291  
BCAM Basal cell adhesion molecule (Lutheran blood group) CCCGCCCCCGCCTTCCC ACGTGGTATC 632 3,205 55 788 58 4 BCAM Ref:BCAM
TPPP3 Tubulin polymerization-promoting protein family member 3 GTGACCCCAAGGCCAGT    82 1 0 57   TPPP3  
C4orf31 Chromosome 4 open reading frame 31 TACATAAAATTAAAGAG TAATCTAAGT 226 429 8 0 57   C4orf31  
GJA5 Gap junction protein, alpha 5, 40kDa GACCATTCCTCGGAGTA AATCTTTGAT 203 122 2 24 55 5 GJA5 RefGJA5
ITGB8 Integrin, beta 8 TCTTGTATCAATGGCAG    633 12 0 52   ITGB8 Ref:ITGB8
TSPAN2 Tetraspanin 2 CCAAGGCACTGAATTAA    143 3 0 49   TSPAN2  
WT1 Wilms tumor 1 CTGGTATATGGCTTCAA TTACAAGATA 406 143 3 0 49   WT1 Ref:WT1
COL4A3 Collagen, type IV, alpha 3 (Goodpasture antigen) TGCATTATTTTCCAGAT    122 3 0 48   COL4A3 REF:COL4A3
ALS2CL ALS2 C-terminal like CGATGCTGACGGGACCC    796 17 0 47   ALS2CL  
PLCE1 Phospholipase C, epsilon 1 AACGAACGTGGCTGTAT    163 4 0 46   PLCE1 Ref:PLCE1
WFS1 Wolfram syndrome 1 (wolframin) ACCCTCCTGTCCAGCAG    204 4 0 46   WFS1  
PCOLCE2 Procollagen C-endopeptidase enhancer 2 ATGGAGGTATGAGGCCT TATGTTCTCT 271 408 9 24 45 17 PCOLCE2  
MRGPRF MAS-related GPR, member F AGGACCCACTGGGCAGC CTCTTAAGGC 316 327 8 0 43   MRGPRF  
SPTB Spectrin, beta, erythrocytic CAATCTGGGGCTGGCCC    82 2 0 42   SPTB Ref:SPTB
ATP10A ATPase, class V, type 10A TCCTCTGCGCCAGGGGA    204 5 0 41   ATP10A  
USHBP1 Usher syndrome 1C binding protein 1 TCATAAACTGTCCTGGA    122 3 0 40   USHBP1  
MAP6 Microtubule-associated protein 6 TACAGTAGTCTTGCTGG    327 8 0 39   MAP6  
NFASC Neurofascin homolog (chicken) AGCAATGAAAAGGCCAA    184 5 0 39   NFASC  
PLA2R1 Phospholipase A2 receptor 1, 180kDa AATTTTGCAAAAAGGAA    82 2 0 39   PLA2R1  
C1QL1 Complement component 1, q subcomponent-like 1 CGCGGCGGCGACGGCAC    184 5 24 39 8 C1QL1  
TMEM178 Transmembrane protein 178 CTTGTTAAATTTTAATG    102 3 24 39 4 TMEM178  
TP53I11 Tumor protein p53 inducible protein 11 TACCCCAAGGCCTGATG    102 3 0 37   TP53I11  
SYNPO Synaptopodin ATATTAGGAAGTCGGGG CATTTCTACC 519 592 16 0 37   SYNPO Ref:SYNPO
DACH1 Dachshund homolog 1 (Drosophila) TAGGACCTATGAAAATT    82 2 0 37   DACH1  
TTMA Two transmembrane domain family member A CTTTATTGAGTGTTATC    225 6 0 37   TTMA  
FABP1 Fatty acid binding protein 1, liver ACATTGGGTGACATTGT    102 3 24 35 4 FABP1  
RAMP3 Receptor (G protein-coupled) activity modifying protein 3 AGCTTGTGGCCTCTATC    1,000 29 0 34   RAMP3  
EMCN Endomucin CTACTTTGTACATATAA TTTTCTTTAA 361 449 13 0 34   EMCN  
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 AGGAGGGGCTGGGACTG    184 6 72 33 3 RAPGEF3  
FAM20B Major histocompatibility complex, class I, B TCCCGGCCCGGCCGCGG    82 2 0 33   FAM20B  
NPNT Nephronectin GTAAAGGTATAAGCCTT CATTTTTAAT 383 286 9 0 32   NPNT Ref:NPNT
UACA Uveal autoantigen with coiled-coil domains and ankyrin repeats AGTTCTGTTTCACAAGT    82 3 0 32   UACA  
KLK7 Kallikrein-related peptidase 7 AGCCACCACGGCCAGCC    592 19 96 31 6 KLK7  
LIMS2 LIM and senescent cell antigen-like domains 2 CAGATGGAGGCCTCTGG    776 25 24 31 32 LIMS2  
TYRO3 TYRO3 protein tyrosine kinase GGGCGGGTCCTAGCTGT    1,143 37 72 31 16 TYRO3  
  1. Transcripts represented by SAGE tags enriched 30 fold or more in glomeruli compared to pooled SAGE libraries from diverse tissues and cells. The gene symbol and gene name are shown for each tag sequence. Where available, the corresponding short Sau3A SAGE tag (Ref 9) is shown. SAGE tag frequencies are shown as Tags per Million (TPM). Sau3A TPM is derived from Ref 9. Enrichment in glomeruli relative to pooled libraries (G:P) and relative to whole kidney (G:K) is shown for each tag. This table with embedded links to SAGE Genie and links to references showing expression and/or function in glomeruli is provided as additional file 3