The importance of iron in long-term survival of maintenance hemodialysis patients treated with epoetin-alfa and intravenous iron: analysis of 9.5 years of prospectively collected data

Table 6 Cox Regression: results of a model in which all data for all units are included.

Factors analyzed	Reference Value*	Hazard Ratio (HR)	HR 95% Confidence Limits
Age at treatment start (per year)		1.045	1.04, 1.05
Co-morbid conditions (None)	≥ 1	0.72	0.60, 0.87
EPO 0–12.1 10³ units/week	> 27.7 10³ units/week	1.5	1.14, 1.96
EPO 12.1 – 27.7 10³ units/week	> 27.7 10³ units/week	1.35	1.10, 1.67
IV iron 0 mg/month	> 455 mg/month	1.27	0.91, 1.77
IV iron 1 – 202 mg/month	> 455 mg/month	0.27	0.20, 0.36
IV iron 202 – 455 mg/month	> 455 mg/month	0.49	0.69, 0.61
Hb ≤ 100 g/L	> 120 g/L	2.83	1.92, 4.16
Hb 100.1 – 110 g/L	> 120 g/L	2.69	1.98, 3.67
Hb 110.1 – 120 g/L	> 120 g/L	1.67	1.31, 2.14
TSAT ≤ 16%	> 25%	1.4	0.92, 2.10
TSAT 16.01 – 20%	> 25%	1.33	0.94, 1.88
TSAT 20.01 - 20%	> 25%	1.41	1.14, 1.76
Serum ferritin ≤ 100 μg/L	> 1000 μg/L	3.64	2.49, 5.32
Serum ferritin 101–300 μg/L	> 1000 μg/L	2.2	1.66, 2.90
Serum ferritin 301–600 μg/L	> 1000 μg/L	1.45	1.11, 1.89
Serum ferritin 601–1000 μg/L	> 1000 μg/L	1.14	0.88, 1.49
Serum albumin ≤ 35 g/L	> 40 g/L	3.41	2.58, 4.50
Serum albumin 35.1–40 g/L	> 40 g/L	1.28	1.05, 1.57
Kt/V ≤ 1.2	> 1.6	2.18	1.56, 3.05
Kt/V 1.21-1.4	> 1.6	1.37	1.03, 1.73
Kt/V 1.41-1.6	> 1.6	0.87	0.70, 1.07

* The numbers of patients in the reference groups are below, in parenthesis: EPO > 27.7 10³ units/week (n = 400); IV iron > 455 mg/month (n = 442); Hb > 120 g/L (n = 442); TSAT > 25% (n = 1303); serum ferritin > 1000 μg/L (n = 266); serum albumin > 40 g/L (n = 688); Kt/V > 1.6 (n = 950)

ISSN: 1471-2369