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Table 6 Coagulation parameters.

From: Citrate- vs. acetate-based dialysate in bicarbonate haemodialysis: consequences on haemodynamics, coagulation, acid-base status, and electrolytes

  

Acetate (A)

Citrate (C)

P(A vs.C)

P (pre-post)

Whole group

     

TAT, ug/l

pre-dialysis

4.34 ± 1.90

4.52 ± 3.29

ns

A < 0.05

 

post-dialysis

7.05 ± 6.14

7.76 ± 8.97

ns

C ns

F1+2, pmol/l

pre-dialysis

275 ± 200

252 ± 183

ns

A ns

 

post-dialysis

277 ± 230

278 ± 281

ns

C ns

Patients with a more pronounced coagulation activation (doubling or more of the pre-dialysis TAT); n = 7; post-hoc analysis

TAT, ug/l

pre-dialysis

5.22 ± 2.22

4.28 ± 1.19

ns

A < 0.01

 

post-dialysis

14.9 ± 6.78

17.0 ± 13.34

ns

C < 0.01

F1+2, pmol/l

pre-dialysis

403 ± 181

374 ± 228

ns

A < 0.05

 

post-dialysis

560 ± 194

577 ± 391

ns

C < 0.05

  1. Pre- and post-dialysis thrombin-antithrombin complexes (TAT) and prothrombin fragments 1+2 (F1+2) using acetate dialysate (A) vs. citrate (C) dialysate without calcium supplementation.