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Table 2 Logistic regression dominant models for association of RAS SNPs with presence of moderate renal dysfunction (GFR < 60 ml/min/1.73 m2) or CHD

From: Genetic polymorphisms of angiotensin-2 type 1 receptor and angiotensinogen and risk of renal dysfunction and coronary heart disease in type 2 diabetes mellitus

 

HPFS (n = 733)

NHS (n = 833)

 
 

Number of cases/Total number with allele (%)

Age-adjusted OR

[95% CI]

Multivariable OR*

[95% CI]

Number of cases/Total number with allele (%)

Age-adjusted OR

[95% CI]

Multivariable OR*

[95% CI]

p-value for sex *SNP interaction

For GFR <60 ml/min/1.73 m 2

       

   AGT1R T573C (C-allele)

54/480

(11%)

0.68

[0.42, 1.09]

0.60

[0.36, 1.00]

68/569 (12%)

1.11

[0.68, 1.82]

0.96

[0.57, 1.61]

0.21

   AGT1R A1166C (C-allele)

51/346

(15%)

1.59

[0.99, 2.49]

1.63

[1.01, 2.65]

50/402 (12%)

1.18

[0.76, 1.83]

1.28

[0.80, 2.04]

0.54

   AGT M235T (Thr)

57/469

(12%)

0.98

[0.61, 1.56]

0.91

[0.55, 1.49]

68/527 (13%)

1.62

[0.99, 2.69]

1.46

[0.85, 2.50]

0.25

For prevalent CHD

       

   AGT1R T573C (C-allele)

133/480 (28%)

1.26

[0.85, 1.85]

1.36

[0.91, 2.02]

148/569 (26%)

1.07

[0.75, 1.53]

1.02

[0.69, 1.49]

0.45

   AGT1R A1166C (C-allele)

105/346 (30%)

1.62

[1.14, 2.29]

1.57

[1.10, 2.24]

99/402 (25%)

0.84

[0.61, 1.16]

0.85

[0.61, 1.20]

0.008

   AGT M235T (Thr)

120/469 (26%)

0.95

[0.66, 1.35]

0.92

[0.64, 1.33]

154/527 (29%)

1.72

[1.20, 2.47]

1.66

[1.13, 2.43]

0.03

  1. *Multivariable models are adjusted for age (continuous, years), hypertension (yes/no), BMI (continuous), cigarette smoking status (never, past, current), physical activity (quartiles, mets/week), time since Type 2 diabetes diagnosis (quartiles, years), and measured HbA1c (quartiles). Multivariable models for renal dysfunction are adjusted for presence of coronary heart disease (yes/no) and multivariable models for CHD are also adjusted for eGFR<60 ml/min/1.73 m2. ACE-inhibitor use did not change point estimates when included in the model and was removed.
  2. GFR < 60 ml/min/1.73 m2 by the 4-variable MDRD equation was considered renal dysfunction. Coronary heart disease was defined as history of confirmed myocardial infarction, or self-reported coronary revascularization or angina.