Figure 4From: Over-expression of adenosine deaminase in mouse podocytes does not reverse puromycin aminonucleoside resistance Effect of PAN treatment on urinary excretion of proteins and sodium. A. Effect of PAN in rats. PAN-treated (150 mg/kg body wt at day 0, solid lines) and -untreated rats (dotted lines) were housed in metabolic cages and their daily excretion of sodium (circles) and proteins (triangles) was monitored for 7 days. Results, expressed as a function of creatinine excretion, are means Ā± SE from 6 rats in each group. Statistical significance between treated and untreated rats was assessed by unpaired Student's t test: **, p < 0,025; ***, p < 0,001. B and C. Effect of PAN in wild type and ADAtg mice. Wild type (dotted lines) and ADAtg mice (solid lines) received a single (B) or two (C) injections of PAN (150 mg/kg body wt at day 0 and day 4, arrows) and were monitored for 7-10 days for urinary excretion of sodium (circles) and proteins (triangles). Results, expressed as a function of creatinine excretion, are means Ā± SE from 6 mice in each group except the ADAtg group treated once (n = 9). Values statistically different from controls (day 0) were assessed by variance analysis followed by Bonferonni test: *, p < 0.05.Back to article page