Over-expression of adenosine deaminase in mouse podocytes does not reverse puromycin aminonucleoside resistance

BMC Nephrology

Table 1 Animal models of proteinuria

Models	Proteinuria	Na handling	Ref
Injection of PAN
Sprague Dawley rat	10 g/mmol creat	Ascites, edema	[9]
	90 mg/mg creat	Ascites, edema	[9]
	3 g/24 h/kg body wt	Ascites, edema	[9]
	30 mg/ml	Ascites, edema	[9]
Wild type B6/D2 mouse	0.03 mg/mg creat		[29]
ApoE^-/- mouse	0.2 mg/ml		[30]
Cox2 tg mouse	0.07 mg/mg creat		[29]
PRO/Re mouse	0.7 g/24 h/kg body wt		[31]
Injection of adriamycin
Sprague Dawley rat	25 mg/mg creat	Na retention	[9]
B6/D2 mouse	0.04 mg/mg creat		[41]
Balb/c mouse	23 mg/mg creat		[42]
Balb/c mouse	226 mg/mg creat		[43]
129 mouse	120 mg/mg creat	Ascites	[44]
Genetically modified mice
Laminin α5^-/-	200 mg/mg creat		[32]
Laminin β2^-/-	12 mg/ml		[33]
α-actinin-4^-/-	+ +		[34]
Nphs2^-/-	+ + +	HTA	[36]
CD2-AP^-/-	+ + +		[35]
CD151^-/-	+ + +	Edema	[27]
Human CD34⁺ engraftment
NOD/SCID mouse	0.04 mg/mg creat		[37]

Proteinuria in PAN nephrotic rats is given as a function of the different units found in the literature. + + and + + + refers to increases in proteinuria as determined by western blotting. When available, functional data related to renal sodium handling are provided; HTA, hypertension.

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