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Table 1 Animal models of proteinuria

From: Over-expression of adenosine deaminase in mouse podocytes does not reverse puromycin aminonucleoside resistance

Models Proteinuria Na handling Ref
Injection of PAN    
   Sprague Dawley rat 10 g/mmol creat Ascites, edema [9]
  90 mg/mg creat Ascites, edema [9]
  3 g/24 h/kg body wt Ascites, edema [9]
  30 mg/ml Ascites, edema [9]
   Wild type B6/D2 mouse 0.03 mg/mg creat   [29]
   ApoE-/- mouse 0.2 mg/ml   [30]
   Cox2 tg mouse 0.07 mg/mg creat   [29]
   PRO/Re mouse 0.7 g/24 h/kg body wt   [31]
Injection of adriamycin    
   Sprague Dawley rat 25 mg/mg creat Na retention [9]
   B6/D2 mouse 0.04 mg/mg creat   [41]
   Balb/c mouse 23 mg/mg creat   [42]
   Balb/c mouse 226 mg/mg creat   [43]
   129 mouse 120 mg/mg creat Ascites [44]
Genetically modified mice    
   Laminin α5-/- 200 mg/mg creat   [32]
   Laminin β2-/- 12 mg/ml   [33]
   α-actinin-4-/- + +   [34]
   Nphs2-/- + + + HTA [36]
   CD2-AP-/- + + +   [35]
   CD151-/- + + + Edema [27]
Human CD34+ engraftment    
   NOD/SCID mouse 0.04 mg/mg creat   [37]
  1. Proteinuria in PAN nephrotic rats is given as a function of the different units found in the literature. + + and + + + refers to increases in proteinuria as determined by western blotting. When available, functional data related to renal sodium handling are provided; HTA, hypertension.