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Table 1 Quantitative micro-CT measurements

From: Atherosclerosis, inflammation and lipoprotein glomerulopathy in kidneys of apoE-/-/LDL-/- double knockout mice

 

C57/BL mouse (Controls)

ApoE-/-/LDL-/-double knockout mouse

Total Vascular Volume Fraction (mm 3 )

4.3 ± 0.4

3.2 ± 0.3*

Venous Vascular Volume Fraction (mm 3 )

3.9 ± 0.3

2.9 ± 0.4*

Arterial Vascular Volume Fraction (mm 3 )

0.4 ± 0.1

0.3 ± 0.1

Maximum Kidney Dimension (mm)

10.6 ± 1.7

11.5 ± 1.9

Number of Glomeruli (per cross-section)

17 ± 3

24 ± 5*

Number of Diseased Glomeruli (per cross-section

0

11 ± 3*

Glomeruli cross-sectional surface area (μm 2 )

3533 ± 358

9959 ± 658*

Diameter Glomerular Capillaries (μm)

8.2 ± 2.3

22.3 ± 3.9*

  1. A significant decrease in the total vascular volume fraction and a significant increase in the total number and area of glomeruli is present in apoE-/-/LDL-/- double knockout mice compared to controls (*p < 0.001). The decrease of the total vascular volume fraction is due to the decrease in the venous vascular volume fraction (p < 0.01). No significant difference in the arterial vascular volume fraction was found between the groups (p < 0.4).