Inclusion Criteria | Exclusion Criteria |
---|---|
Patients undergoing primary liver transplantation. | Patients with pre-transplant renal replacement therapy > 14 days. |
Patients older than 18 years. | Patients with platelets < 50.000/nl. |
eGFR < 50 ml/min at the time point of transplantation | Patients with triglycerides > 350 mg/dl and cholesterol > 300 mg/dl refractory to optimal medical treatment prior to initiation of therapy with mTOR inhibition. |
Serum creatinine levels > 1.5 mg/dL at the time-point of transplantation | Multiple organ graft recipients. |
Patients with eGFR < 50 ml/min at the time point of transplantation or Serum creatinine levels > 1.5 mg/dL at the time-point of transplantation | Patients with signs of a hepatic artery stenosis directly prior to initiation of therapy with Sirolimus. |
 | Patients with a psychological, familial, sociologic or geographic condition potentially hampering compliance with the study protocol and follow-up schedule. |
 | Patients under guardianship (e.g. individuals who are not able to freely give their informed consent). |