| Baseline | Post 0-60 | Post 60-120 | Post 120-180 | Post 180-240 | Post 240-300 | P (GLM-within) |
---|
AVP (pmol/l)
|
Group 1 | 1.00(0.40) | 0.7(0.10) * | 0.60(0.25)* | 0.70(0.35)* | 0.90(0.65) | 1.00(0.45) | 0.000 |
Group 2 | 0.75(0.45) | 0.60(0.08)* | 0.60(0.18)* | 0.60(0.10)* | 0.70(0.60) | 0.80(0.45) |
Group 3 | 0.70(0.53) | 0.60(0.08)* | 0.60(0.15)* | 0.60(0.15)* | 0.65(0.63) | 0.80(0.60) |
Group 4 | 1.80(1.85) | 1.10(0.83)* | 1.10(0.88)* | 1.30(0.93)* | 1.50(0.85)* | 1.65(1.25)* |
P (GLM-between) | 0.000 |
P (Kruskal-Wallis) | 0.000 | 0.000 | 0.000 | 0.000 | 0.001 | 0.002 | Â |
P-osm (mosmol/l)
|
Group 1 | 290(6) | 283(3) * | 284(6)* | 287(5)* | 286(5)* | 287(4) | 0.000 |
Group 2 | 288(7) | 283(8)* | 284(8)* | 286(9)* | 286(9)* | 288(8) |
Group 3 | 291(11) | 285(7)* | 287(9)* | 289(6)* | 288(4)* | 289(6)* |
Group 4 | 305(14) | 299(15)* | 298(14)* | 297(14)* | 297(14)* | 299(13)* |
P (GLM-between) | 0.000 |
P (Kruskal-Wallis) | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | Â |
- Blood samples were drawn after a baseline period of 120 minutes, and after the end of five consecutive periods each of one hour duration (Post 0-60, Post 60-120, Post 120-180, Post 180-240, and Post 240-300. An oral water load of 20 ml/kg body weight was given during the first 15 minutes of the Post 0-60 period. Group 1 comprised healthy control subjects (n = 10). Groups 2-4 comprised patients with chronic kidney disease or hyperension (Group 2 (n = 14), e-GFR ≥ 90 ml/min; Group 3 (n = 11), 60 ml/min ≤ e-GFR < 90 ml/min; and Group 4 (n = 16), 15 ml/min < e-GFR ≤ 60 ml/min).
- Median with Interquartile Range in brackets. A General Linear Model (GLM) for Repeated Measures was used for comparison within and between groups. Kruskal-Wallis's test was used to analyze differences between groups during the diluting test. Wilcoxon's signed rank test was used in each group to analyze significant deviations from baseline (* = P < 0.05).