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Table 3 Plasma concentration of vasopressin (p-AVP) and plasma osmolaririty (p-osm) during urine diluting test.

From: Abnormal function of the vasopressin-cyclic-AMP-aquaporin2 axis during urine concentrating and diluting in patients with reduced renal function. A case control study

 

Baseline

Post

0-60

Post

60-120

Post

120-180

Post

180-240

Post

240-300

P

(GLM-within)

AVP (pmol/l)

Group 1

1.00(0.40)

0.7(0.10) *

0.60(0.25)*

0.70(0.35)*

0.90(0.65)

1.00(0.45)

0.000

Group 2

0.75(0.45)

0.60(0.08)*

0.60(0.18)*

0.60(0.10)*

0.70(0.60)

0.80(0.45)

Group 3

0.70(0.53)

0.60(0.08)*

0.60(0.15)*

0.60(0.15)*

0.65(0.63)

0.80(0.60)

Group 4

1.80(1.85)

1.10(0.83)*

1.10(0.88)*

1.30(0.93)*

1.50(0.85)*

1.65(1.25)*

P (GLM-between)

0.000

P (Kruskal-Wallis)

0.000

0.000

0.000

0.000

0.001

0.002

 

P-osm (mosmol/l)

Group 1

290(6)

283(3) *

284(6)*

287(5)*

286(5)*

287(4)

0.000

Group 2

288(7)

283(8)*

284(8)*

286(9)*

286(9)*

288(8)

Group 3

291(11)

285(7)*

287(9)*

289(6)*

288(4)*

289(6)*

Group 4

305(14)

299(15)*

298(14)*

297(14)*

297(14)*

299(13)*

P (GLM-between)

0.000

P (Kruskal-Wallis)

0.000

0.000

0.000

0.000

0.000

0.000

 
  1. Blood samples were drawn after a baseline period of 120 minutes, and after the end of five consecutive periods each of one hour duration (Post 0-60, Post 60-120, Post 120-180, Post 180-240, and Post 240-300. An oral water load of 20 ml/kg body weight was given during the first 15 minutes of the Post 0-60 period. Group 1 comprised healthy control subjects (n = 10). Groups 2-4 comprised patients with chronic kidney disease or hyperension (Group 2 (n = 14), e-GFR ≥ 90 ml/min; Group 3 (n = 11), 60 ml/min ≤ e-GFR < 90 ml/min; and Group 4 (n = 16), 15 ml/min < e-GFR ≤ 60 ml/min).
  2. Median with Interquartile Range in brackets. A General Linear Model (GLM) for Repeated Measures was used for comparison within and between groups. Kruskal-Wallis's test was used to analyze differences between groups during the diluting test. Wilcoxon's signed rank test was used in each group to analyze significant deviations from baseline (* = P < 0.05).