Independent variables | B | SE | β | t | P |
---|
P-AVP (pmol/l) | 5.184 | 5.844 | 0.154 | 0.887 | 0.381 |
U-c-AMP (pmol/l) | -0.002 | 0.003 | -0.93 | -0.586 | 0.562 |
U-AQP2 (ng/ml) | -13.270 | 8.415 | -0.242 | -1.577 | 0.123 |
SBP (mm Hg) | 0.035 | 0.472 | 0.015 | 0.075 | 0.940 |
DBP (mm Hg) | -0.366 | 0.721 | -0.105 | -0.507 | 0.615 |
E-GFR (ml/min) | 0.487 | 0.159 | 0.613 | 3.066 | 0.004 |
- The amount of water excreted during the first four hours after water loading in percent of the given water load during the urine diluting test (20 ml/kg/body weight) as dependent variable and plasma concentration of vasopressin (p-AVP), urinary excretions of cyclic AMP (u-c-AMP) and aquaporin2 (AQP2), 24 hours systolic and diastolic blood pressure (SBP and DBP), and estimated GFR (e-GFR) as independent variables in a multiple regression analysis at the start of the urine diluting test in the whole study population (n = 41) comprising healthy control subjects (n = 10) and patients with chronic kidney disease or hypertension (n = 31; Group 2 (n = 14), e-GFR ≥ 90 ml/min; Group 3 (n = 11), 60 ml/min ≤ e-GFR < 90 ml/min; and Group 4 (n = 16), 15 ml/min < e-GFR ≤ 60 ml/min).
- Unstandardized partial regression coefficients (Β), standard error (SE), standardized partial regression coefficient (β), t- value (t), and significance (P)