Table 1 Overview of the study design
Day 1 | Day 2 | Examination day | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Time | 7:00 AM | 3:00 PM | 11:00 PM | 7:00 AM | 3:00 PM | 11:00 PM | 7:00 AM | 8:00 AM | 9:00 AM | 9:30 AM | 10:00 AM | 10:30 AM | 11:00 AM | 11:30 AM | 12:00 AM | 12:30 AM | 13:00 AM |
Food | specified diet | Fasting | Fasting | ||||||||||||||
Water | 35 ml/kg body weight | 35 ml/kg body weight | 175 ml every ½ hour | ||||||||||||||
Ibuprofen/placebo | x | x | x | x | |||||||||||||
Urine samples | 24 hour urine collection | 2 ½ hour urine collection | Baseline urine collection | 1 | 2 | 3 | 4 | ||||||||||
Blood samples | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | |||||||
3% saline infusion | 7 ml/kg body weight | ||||||||||||||||