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Table 3 Urinary aquaporin-2 creatinine adjusted (U-AQP2/u-crea), urinary epithelial Na+ channel (U-ENaCβ/u-crea), plasma arginine vasopressin (AVP), urine osmolality (U-OSM), serum osmolality (S-OSM), urinary excretion of prostaglandin2 (U-PGE2), free water clearance (CH2O), urinary excretion of cAMP (U-CAMP), and Glomerular filtration rate (GFR).

From: Increased renal sodium absorption by inhibition of prostaglandin synthesis during fasting in healthy man. A possible role of the epithelial sodium channels

  

Baseline

30 min

60 min

90 min

120

P

U-AQP2/u-crea (ng/μmol)

       
 

Placebo

154(33)

189(69) **

200(61) ***

225(75) ***

233(76) ***

0.005

 

Ibuprofen

161 (25)

161(62)

202(68)*

199(52)**

208(64)**

 
 

P-value

NS

0.036

NS

0.008

0.014

 

U-EnaC/u-crea (pg/μmol) Placebo

 

11.6(3)

13.4(3) **

12.8(4)

13.4(4)

13.7(4) **

< 0.0001

 

Ibuprofen

44.8(13)

44.1 (10)

38.6 (10) **

39.1 (10) **

35.8 (9) ***

 
 

P-Value

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

 

P-AVP (pg/ml)

       
 

Placebo

0.87(0.5)

1.9(0.13) ***

1.5(0.12) ***

1.3(0.13) ***

1.2(0.9) ***

NS

 

Ibuprofen

0.91(0.5)

1.9(0.15) ***

1.5(0.11) ***

1.4(0.10) ***

1.2(0.9) ***

 

U-OSM (mosm/kg H2O)

       
 

Placebo

130(25)

335(77) ***

588(113) ***

585(11) ***

566(110) ***

NS

 

Ibuprofen

125(31)

331(107) ***

631(201) ***

625(119) ***

612(130) ***

 

S-OSM (mosm/kg H2O)

       
 

Placebo

283(2.7)

291(4.1) ***

290(3.2) ***

289(3.6) ***

287(3.7) ***

NS

 

Ibuprofen

283(3.0)

293(3.7) ***

291(2.6) ***

289(3.2) ***

287(3.5) ***

 

U-PGE2 (pg/min)

       
 

Placebo

281(123)

212(105)

256(118)

293(133)

298(173)

<0.001

 

Ibuprofen

507(341)

385(180)

415(138)

406(160)

507(411)

 
 

P-Value

0.02

0.001

0.0004

0.005

0.02

 

CH2O (ml/min)

       
 

Placebo

4.05(1.2)

-0.38(0.5) ***

-1.60(0.6) ***

-2.00(0.7) ***

-2.00(0.7) ***

NS

 

Ibuprofen

3.70(1.4)

-0.20(1.0) ***

-1.62(0.8) ***

-1.92(0.7) ***

-2.00(0.7) ***

 

Urine (ml/min)

Placebo

7.02(1.57)

3.0(0.19)***

1.8(0.20)***

2.16(0.20)***

2.3(0.20)***

<0.0001

 

Ibuprofen

6.31(1.71)

2.8 (0.23)***

1.6(0.12)***

1.7(0.11)***

1.9(0.13)***

 
 

P-Value

NS

NS

NS

0.016

NS

 

U-CAMP (pmol/min)

       
 

Placebo

3819(1034)

3974(1251)

4285(1387)

4114(1353)

4219(1125)

NS

 

Ibuprofen

4016(1180)

3738(759)

4447(1243)

4196(1248)

4377(1136)

 

GFR (ml/min)

      
 

Placebo

98(12)

94(16)

94(21)

103(21)

102(17)

NS

 

Ibuprofen

98(13)

93(18)

98(15)

101(16)

103(12)

 
  1. Baseline values before hypertonic saline infusion, 30, 60, 90 and 120 min after hypertonic saline infusion in 17 healthy humans administered with ibuprofen or placebo.
  2. Values are means and (SD). P indicates significant difference between ibuprofen treatment and placebo using a General Linear Model With Repeated Measures. A paired t-test was used for comparison of means, when differences were found between the two treatments. *indicated a statistical significant changed from baseline values* P < 0.05 ** P < 0.01, *** P < 0.001.(longitudinal comparison)
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BMC Nephrology

ISSN: 1471-2369

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