Table 4 Effect of Ibuprofen on plasma atrial natriuretic peptide (p-ANP), plasma brain natriuretic peptide (p-BNP), plasma angiotensin II (p-AngII) and p-aldosterone (p-Aldo) at morning after 24 hours of fasting (morning), before hypertonic saline infusion (baseline), 60 min. after hypertonic saline infusion (60 min. post) and 120 min. after hypertonic saline infusion (120 min. post) compared with placebo in a randomized clinical trial with17 healthy subjects
Morning | Baseline | 60 min. post. | 120 min. post. | P | ||
|---|---|---|---|---|---|---|
p-ANP (pmol/l) | ||||||
Placebo | 5.95(3.37) | 5.75(2.68) | 9.84 (3.89) | 8.39(4.03) | NS | |
Ibuprofen | 6.80(3.22) | 7.44(3.46) | 11.85(5.54) | 9.13 (3.78) | ||
p-BNP (pmol/l) | ||||||
Placebo | 1.59(1.10) | 1.65(0.99) | 2.66 (2.26) | 2.17 (1.55) | 0.015 | |
Ibuprofen | 2.57(2.08) | 2.65(2.03) | 3.44 (3.27) | 3.09 (2.38) | ||
p-value | 0.025 | 0.004 | NS | 0.015 | ||
p-Renin (mU/l) | ||||||
Placebo | 10.1(5.3) | 12.2(7.8) | 9.5(14.7) | 5.5 (2.1) | NS | |
Ibuprofen | 10.7(12.3) | 13.6(22.1) | 12.5 (21.3) | 4.9 (2.5) | ||
p-AngII(pmol/l | ||||||
Placebo | 8.2 (3.0) | 10.5 (5.9) | 6.5(4.4) | 6.2 (3.5) | NS | |
Ibuprofen | 7.1 (3.4) | 7.6 (4.6) | 5.9 (4.0) | 5.2 (2.7) | ||
p-Aldo (pmol/l) | ||||||
Placebo | 310.8 (211.6) | 230.4 (145.5) | 164.7 (63.0) | 162.4 (57.1) | NS | |
Ibuprofen | 293.9 (137.6) | 190.9 (55.6) | 156.6 (27.3) | 161.6 (36.6) |