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Table 4 Effect of Ibuprofen on plasma atrial natriuretic peptide (p-ANP), plasma brain natriuretic peptide (p-BNP), plasma angiotensin II (p-AngII) and p-aldosterone (p-Aldo) at morning after 24 hours of fasting (morning), before hypertonic saline infusion (baseline), 60 min. after hypertonic saline infusion (60 min. post) and 120 min. after hypertonic saline infusion (120 min. post) compared with placebo in a randomized clinical trial with17 healthy subjects

From: Increased renal sodium absorption by inhibition of prostaglandin synthesis during fasting in healthy man. A possible role of the epithelial sodium channels

   Morning Baseline 60 min. post. 120 min. post. P
p-ANP (pmol/l)       
  Placebo 5.95(3.37) 5.75(2.68) 9.84 (3.89) 8.39(4.03) NS
  Ibuprofen 6.80(3.22) 7.44(3.46) 11.85(5.54) 9.13 (3.78)  
p-BNP (pmol/l)       
  Placebo 1.59(1.10) 1.65(0.99) 2.66 (2.26) 2.17 (1.55) 0.015
  Ibuprofen 2.57(2.08) 2.65(2.03) 3.44 (3.27) 3.09 (2.38)  
  p-value 0.025 0.004 NS 0.015  
p-Renin (mU/l)       
  Placebo 10.1(5.3) 12.2(7.8) 9.5(14.7) 5.5 (2.1) NS
  Ibuprofen 10.7(12.3) 13.6(22.1) 12.5 (21.3) 4.9 (2.5)  
p-AngII(pmol/l       
  Placebo 8.2 (3.0) 10.5 (5.9) 6.5(4.4) 6.2 (3.5) NS
  Ibuprofen 7.1 (3.4) 7.6 (4.6) 5.9 (4.0) 5.2 (2.7)  
p-Aldo (pmol/l)       
  Placebo 310.8 (211.6) 230.4 (145.5) 164.7 (63.0) 162.4 (57.1) NS
  Ibuprofen 293.9 (137.6) 190.9 (55.6) 156.6 (27.3) 161.6 (36.6)  
  1. Values are means and (SD). P indicates significant difference between ibuprofen treatment and placebo using a General Linear Model With Repeated Measures. A paired t-test was used for comparison of means, when differences were found between the two treatments.