Table 1 Significance analysis of CKD markers in urine of microalbuminuric patients before and after two year treatment
CKD marker | Sequence | Peptide name | Wilcoxon p-value (Irbesaran treatment) | Wilcoxon p-value (Placebo intake) | Irbesartan treatment | Placebo intake |
|---|---|---|---|---|---|---|
2505 | SpGEAGRpG | Collagen alpha-1 (I) chain [522-530] | 1.58E-02 | n.s. | ↑ | - |
3508 | GPpGPpGPpG | Collagen alpha-1 (I) chain [145-154] | 1.58E-02 | n.s. | ↑ | - |
11982 | YQTNKAKH | Cystatin-B [85-92] | 2.55E-03 | n.s. | ↓ | - |
13342 | ApGDKGESGPS | Collagen alpha-1 (I) chain [777-787] | 4.46E-02 | 8.33E-03 | ↑ | ↓ |
14906 | MGPRGPpGPpG | Collagen alpha-1 (I) chain [217-227] | n.s. | 1.94E-02 | - | ↓ |
15800 | GEYKFQNAL | Serum albumin [423-431] | 1.53E-03 | n.s. | ↑ | - |
17694 | ApGDRGEpGPp | Collagen alpha-1 (I) chain [798-808] | 5.39E-05 | n.s. | ↑ | - |
24117 | SpGPDGKTGPPGp | Collagen alpha-1 (I) chain [546-558] | 3.02E-02 | 1.58E-02 | ↑ | ↓ |
24958 | GPpGPDGNKGEpG | Collagen alpha-2 (I) chain [613-625] | 1.84E-02 | n.s. | ↑ | - |
25053 | GPpGEAGKpGEQG | Collagen alpha-1 (I) chain [650-662] | 1.25E-03 | n.s. | ↑ | - |
28747 | SpGERGETGPpGP | Collagen alpha-1 (III) chain [796-808] | 4.10E-03 | n.s. | ↑ | - |
38780 | GLpGTGGPpGENGKpG | Collagen alpha-1 (III) chain [642-657] | n.s. | 2.62E-02 | - | ↓ |
55523 | SpGSNGApGQRGEpGPQG | Collagen alpha-1 (III) chain [358-375] | n.s. | 4.47E-02 | - | ↓ |
61573 | DEAGSEADHEGTHSTKR | Fibrinogen alpha chain [605-621] | 1.92E-02 | n.s. | ↑ | - |
73177 | DAGApGAPGGKGDAGApGERGPpG | Collagen alpha-1 (III) chain [664-687] | 7.81E-03 | n.s. | ↓ | - |
73697 | GNSGEpGApGSKGDTGAKGEPGp | Collagen alpha-1 (I) chain [431-453] | n.s. | 3.51E-02 | - | ↓ |
78332 | AGPpGEAGKpGEQGVpGDLGAPGP | Collagen alpha-1 (I) chain [646-669] | 1.04E-02 | n.s. | ↓ | - |
81196 | NGApGNDGAkGDAGApGAPGSQGApG | Collagen alpha-1 (I) chain [700-725] | 2.33E-02 | n.s. | ↓ | - |
82026 | GNSGEpGApGSKGDTGAKGEpGPVG | Collagen alpha-1 (I) chain [431-455] | 2.71E-02 | n.s. | ↓ | - |
94308 | TGPIGPpGPAGApGDKGESGPSGPAGPTG | Collagen alpha-1 (I) chain [766-794] | 1.30E-02 | n.s. | ↓ | - |
96370 | LmIEQNTKSPLFMGKVVNPTQK | Alpha-1-antitrypsin [397-418] | 4.47E-02 | n.s. | ↑ | - |
118224 | ESGREGApGAEGSpGRDGSpGAKGDRGETGPA | Collagen alpha-1 (I) chain [1011-1042] | n.s. | 6.94E-03 | - | ↓ |
143947 | DQGPVGRTGEVGAVGPpGFAGEKGPSGEAGTAGPpGTpGPQG | Collagen alpha-2 (I) chain [824-865] | 1.59E-03 | n.s. | ↓ | - |