Figure 1
From: Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis
Real-time PCR analysis: the BMP-7 mRNA level is decreased in the tubulointerstitium but not in the glomeruli of patients with sclerotic compared to normal kidney tissue. Real time PCR with BMP-7 in normal kidneys (n = 10) and those from patients with nephrosclerosis (n = 32), housekeeping gene PPIA. Relative BMP-7 mRNA transcription in the tubulointerstitium and glomeruli of the kidneys are shown. BMP-7 mRNA was significantly decreased in the tubulointerstitium of patients with nephrosclerosis compared to normal kidneys (p < 0.01; Kruskal-Wallis test followed by Mann-Whitney-U test). The BMP-7 mRNA level in the glomeruli did not differ significantly. The results are displayed as medians with quartiles.