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Figure 9 | BMC Nephrology

Figure 9

From: Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis

Figure 9

Figure 9A - Smad 1/5/8 is decreased by angiotensin-II. Western Blotting was performed in HK-2 cells for phosphorylated Smad 1/5/8 after stimulation with AT-II (10-3 mM, n = 3). Phosphorylated Smad 1/5/8 was significantly decreased in HK-2 cells after stimulation with AT-II (p < 0.05). Figure 9B - BMP-7 attenuates TGF-β induced pSmad 2. Western blotting was performed in HK-2 cells for phosphorylated Smad 2 after stimulation with TGF-β alone (10 ng/ml) and TGF-β in combination with BMP-7 (100 ng/ml, n = 3). Phosphorylated Smad 2 was increased after stimulation with TGF-β alone and significantly decreased after stimulation with TGF-β in combination with BMP-7 (p < 0.05).

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