Table 1 Baseline characteristics
From: Macrocytosis may be associated with mortality in chronic hemodialysis patients: a prospective study
Variable | All (n = 150) | MCV ≤ 102 fl (n = 105) | MCV > 102 fl (n = 45) | P |
|---|---|---|---|---|
Demographic | ||||
Age (years) | 65.0 ± 17.0 | 63.3 ± 17.6 | 68.9 ± 15.1 | 0.07 |
Time on dialysis (months) | 34.5 ± 31.8 | 33.8 ± 34.4 | 36.4 ± 24.6 | 0.65 |
Male n (%) | 76 (51) | 58 (55) | 18 (40) | 0.09 |
Caucasian n (%) | 135 (90) | 91 (87) | 44 (98) | 0.04 |
Fistula as HD access n (%)* | 45 (30) | 33 (31) | 12 (27) | 0.56 |
Cause of ESRD n (%) | ||||
Diabetes | 51 (34) | 40 (38) | 11 (24) | 0.11 |
Glomerulonephritis | 29 (19) | 18 (17) | 11 (24) | 0.30 |
Comorbidities n (%) | ||||
Diabetes | 63 (42) | 45 (43) | 18 (40) | 0.75 |
Hypertension | 114 (76) | 79 (75) | 35 (78) | 0.74 |
Coronary artery disease | 53 (35) | 39 (37) | 14 (31) | 0.54 |
Peripheral vascular disease | 33 (22) | 23 (22) | 10 (22) | 0.97 |
Stroke | 21 (14) | 14 (13) | 7 (16) | 0.72 |
Cancer | 25 (17) | 11 (10) | 14 (31) | < 0.01 |
Failed renal transplant | 25 (17) | 20 (19) | 5 (11) | 0.24 |
Charlson-Age Comorbidity Index | 7 ± 3 | 6 ± 3 | 8 ± 3 | 0.01 |
Laboratory | ||||
Mean MCV (fl) | 99.1 ± 6.4 | 96.0 ± 4.6 | 106.3 ± 3.1 | < 0.01 |
Albumin (g/L) | 33.7 ± 3.5 | 34.0 ± 3.6 | 33.0 ± 3.3 | 0.14 |
Hemoglobin (Hb) (g/L) | 108.6 ± 10.0 | 109.8 ± 10.0 | 105.7 ± 9.6 | 0.02 |
Hb btw. 100-120 g/L n (%) | 103 (69) | 73 (70) | 30 (67) | 0.65 |
Ferritin ug/L | 729 ± 467 | 707 ± 454 | 782 ± 498 | 0.37 |
Tsat (%) | 29.77 ± 11.80 | 28.05 ± 11.37 | 33.76 ± 11.93 | < 0.01 |
Darbepoetin alfa to Hb ratio | 5.37 ± 3.66 | 4.80 ± 3.49 | 6.69 ± 3.73 | < 0.01 |
Medications | ||||
Darbepoetin alfa dose mcg/week | 43.0 ± 31.5 | 39.3 ± 31.1 | 51.6 ± 31.1 | 0.03 |
Receiving darbepoetin alfa n (%)+ | 141 (94) | 97 (92) | 44 (98) | 0.27 |
Receiving intravenous iron n (%)+ | 137 (91) | 96 (91) | 41 (91) | 0.95 |
Antiepileptic n (%) | 5 (3) | 1 (1) | 4 (9) | 0.01 |
On folate n (%) | 148 (99) | 103 (98) | 45 (100) | 0.81 |
On multivitamin | 143 (95) | 101 (96) | 42 (93) | 0.26 |