| Cases†(n = 102) | Controls (n = 94) | P value |
---|---|---|---|
Age | 66 ± 10 | 66 ± 9 | 0.60 |
Male | 85% | 86% | 0.86 |
Race | Â | Â | 0.90 |
   Whites | 57% | 54% |  |
   Blacks | 20% | 20% |  |
   Other | 23% | 26% |  |
Body Mass Index (BMI) (mean) | 30 (6.4) | 29 (5.3) | 0.25 |
Diabetes | 34% | 27% | 0.24 |
SBP | 134 (19.2) | 134 (21.3) | 0.99 |
DBP | 76 (10.6) | 77 (11.5) | 0.46 |
Smoking status (Y) | 20% | 13% | 0.21 |
ACE/ARB use | 63% | 50% | 0.07 |
Satins use | 68% | 79% | 0.08 |
Albumin-creatinine ratio (median) | 9 (7-25) | 8 (5-13) | 0.53 |
Baseline CrCl (mean) | 93 ± 23 | 113 ± 30 | <0.001 |
Final CrCl (mean) | 52 ± 13 | 95 ± 25 | <0.001 |
Change in CrCl (mean) | -42 ± 20 | -18 ± 25 | <0.001 |
Baseline serum creatinine | 1.08 | 0.96 | <0.001 |
Final serum creatinine | 1.44 | 1.06 | <0.001 |
Change in creatinine | 0.36 | 0.10 | <0.001 |
Baseline eGFRcr | 74 | 85 | <0.001 |
Final eGFRcr | 55 | 75 | <0.001 |
Change in eGFRcr | 19 | 10 | <0.001 |
Uromodulin concentration (mg/dL)* (median, IQR) | 44 (26-85) | 48 (23-80) | 0.88 |
Urine uromodulin-creatinine ratio (mg/g) (median, IQR) | 51 (26-75) | 47 (23-83) | 0.34 |
24-hour urine uromodulin (mg) (median, IQR) | 71 (35-110) | 77 (39-121) | 0.75 |
Odds of Incident CKD | Â | Â | Â |
   Uromodulin concentration (per SD) | 1.05 (0.73-1.51) | Reference | 0.78 |
   Urine uromodulin-creatinine ratio (per SD) | 1.05 (0.77-1.43) | Reference | 0.76 |
   24-hour urine uromodulin concentration (per SD) | 1.01 (0.74-1.36) | Reference | 0.97 |
Genotype Frequencies: | Â | Â | 0.33 |
   G/G genotype frequency | 79% | 72% |  |
   G/T genotype frequency | 19% | 22% |  |
   T/T genotype frequency | 2% | 5% |  |