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Table 3 Association of Baseline Uromodulin with Incident CKD in a Nested Case-Control Design

From: Uromodulin concentrations are not associated with incident CKD among persons with coronary artery disease

 

Cases†

(n = 102)

Controls

(n = 94)

P value

Age

66 ± 10

66 ± 9

0.60

Male

85%

86%

0.86

Race

  

0.90

   Whites

57%

54%

 

   Blacks

20%

20%

 

   Other

23%

26%

 

Body Mass Index (BMI) (mean)

30 (6.4)

29 (5.3)

0.25

Diabetes

34%

27%

0.24

SBP

134 (19.2)

134 (21.3)

0.99

DBP

76 (10.6)

77 (11.5)

0.46

Smoking status (Y)

20%

13%

0.21

ACE/ARB use

63%

50%

0.07

Satins use

68%

79%

0.08

Albumin-creatinine ratio (median)

9 (7-25)

8 (5-13)

0.53

Baseline CrCl (mean)

93 ± 23

113 ± 30

<0.001

Final CrCl (mean)

52 ± 13

95 ± 25

<0.001

Change in CrCl (mean)

-42 ± 20

-18 ± 25

<0.001

Baseline serum creatinine

1.08

0.96

<0.001

Final serum creatinine

1.44

1.06

<0.001

Change in creatinine

0.36

0.10

<0.001

Baseline eGFRcr

74

85

<0.001

Final eGFRcr

55

75

<0.001

Change in eGFRcr

19

10

<0.001

Uromodulin concentration (mg/dL)* (median, IQR)

44 (26-85)

48 (23-80)

0.88

Urine uromodulin-creatinine ratio (mg/g) (median, IQR)

51 (26-75)

47 (23-83)

0.34

24-hour urine uromodulin (mg) (median, IQR)

71 (35-110)

77 (39-121)

0.75

Odds of Incident CKD

   

   Uromodulin concentration (per SD)

1.05 (0.73-1.51)

Reference

0.78

   Urine uromodulin-creatinine ratio (per SD)

1.05 (0.77-1.43)

Reference

0.76

   24-hour urine uromodulin concentration (per SD)

1.01 (0.74-1.36)

Reference

0.97

Genotype Frequencies:

  

0.33

   G/G genotype frequency

79%

72%

 

   G/T genotype frequency

19%

22%

 

   T/T genotype frequency

2%

5%

 
  1. †cases and controls matched on age, sex, and race
  2. *UMOD non-detectables set as zero; no difference when excluded non-detectables.
  3. CrCl = creatinine clearance
  4. IQR = interquartile range; SD = standard deviation