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Table 1 Characteristics of index cases and families with suspected PH1

From: Selected AGXT gene mutations analysis provides a genetic diagnosis in 28% of Tunisian patients with primary hyperoxaluria

Characteristics of index cases (n = 46)
Median and [range]of age( years) 13 [range 0.25 - 61]
Sex-ratio (male/female) 1.09 (24/22)
Oxalate/creatinine (mmol/mmol) 0.37 ± 0.71
Mortality (6)
Systemic symptoms (18)
Age of patients at presentation (n = 46) %
< 1 yr (8) 17.4
1-10 yr (16) 34.7
11-20 yr (8) 17.4
> 20 yr (14) 30.4
Renal insufficiency   
   with nephrocalcinosis only (8) 17.4
   with urolithiasis (21) 45.6
   With both nephrocalcinosis and urolithiasis (17) 37
CRF (13) 28.2
ESRD   
   Hemodialysis (26) 56.5
   Peritoneal Dialysis (7) 15.2
Characteristics of families (n = 40) %
Geographic origin of families   
   North (2) 5
   Centre (8) 20
   Sahel (11) 27.5
   South (19) 47.5
Consanguinity in families   
   Present (30) 75
   Absent (10) 25
  1. Oxalate/creatinine (mmol/mmol) ratio with relevant reference for age as reported by
  2. Belhaj et al 2009 (22): 0-6 months: 0.36; 7-24 months: 0.17; 2-5 years: 0.10; > 5 years: 0.081