Skip to main content

Table 2 Mechanistic studies: Characteristics of the AKI study subjects versus healthy controls

From: Renal kallikrein excretion and epigenetics in human acute kidney injury: Expression, mechanisms and consequences

Characteristics Established AKI patients (n = 20) Healthy controls (n = 38) P value*
Age, years 48.8 ± 3.5 46.3 ± 1.5 0.52
Sex (male/female), n 15/5 30/8 1
Ethnicity, n    0.6
   White 11 20  
   Black 3 6  
   Hispanic 5 6  
   Other 1 6  
Weight, kg 91.2 ± 6.2 93.9 ± 3.7 0.293
BMI, kg/m 2 31.1 ± 2.2 27.8 ± 1 0.177
Laboratory findings at enrollment    
   sCr, mg/dl 2.7 ± 0.47 0.9 ± 0.04 0.0007
   eGFR, ml/min 44.4 ± 7.5 97.5 ± 3.6 < 0.0001
   uNa+/uCr, mEq/gm 127.6 ± 22.5 125.4 ± 9.4 0.347
   uCr/sCr, ratio 42.4 ± 7.2 119.6 ± 11.4 < 0.0001
   FeNa+, % 1.7 ± 0.4 0.8 ± 0.1 0.05
Vital signs at enrollment    
   Systolic BP, mmHg 119.8 ± 4.4 131.4 ± 1.7 0.02
   Diastolic BP, mmHg 70.7 ± 3.4 74.7 ± 1.5 0.3
   Heart rate, beats/min 89.3 ± 3.6 68.0 ± 1.6 < 0.0001
Contributing causes to AKI, n (with urine KLK1 activity excretion, U/gm creatinine, mean ± SEM)    0.83
   Ischemia 7 (6.0 ± 3.7) - -
   Nephrotoxins 4 (7.2 ± 3.9) - -
   Septic 1 (4.6) - -
   Multifactorial causes/other 8 (7.6 ± 2.9) - -
  1. AKI = acute kidney injury, n = number of study subjects, BMI = body mass index, s = serum, u = urine, Cr = creatinine, FeNa+ = fractional excretion of sodium, SBP = systolic blood pressure, DBP = diastolic blood pressure, HR = heart rate, bpm = beats per minute, ICU = intensive care unit. *P values were calculated with Fisher's exact test for categorical variables, and ANOVA (log-transformed, adjusted for covariates: age, sex) for continuous variables. Plus-minus values are mean ± one SEM. Bold: p ≤ 0.05.