Characteristics | Established AKI patients (n = 20) | Healthy controls (n = 38) | P value* |
---|---|---|---|
Age, years | 48.8 ± 3.5 | 46.3 ± 1.5 | 0.52 |
Sex (male/female), n | 15/5 | 30/8 | 1 |
Ethnicity, n | Â | Â | 0.6 |
   White | 11 | 20 |  |
   Black | 3 | 6 |  |
   Hispanic | 5 | 6 |  |
   Other | 1 | 6 |  |
Weight, kg | 91.2 ± 6.2 | 93.9 ± 3.7 | 0.293 |
BMI, kg/m 2 | 31.1 ± 2.2 | 27.8 ± 1 | 0.177 |
Laboratory findings at enrollment | Â | Â | Â |
   sCr, mg/dl | 2.7 ± 0.47 | 0.9 ± 0.04 | 0.0007 |
   eGFR, ml/min | 44.4 ± 7.5 | 97.5 ± 3.6 | < 0.0001 |
   uNa+/uCr, mEq/gm | 127.6 ± 22.5 | 125.4 ± 9.4 | 0.347 |
   uCr/sCr, ratio | 42.4 ± 7.2 | 119.6 ± 11.4 | < 0.0001 |
   FeNa+, % | 1.7 ± 0.4 | 0.8 ± 0.1 | 0.05 |
Vital signs at enrollment | Â | Â | Â |
   Systolic BP, mmHg | 119.8 ± 4.4 | 131.4 ± 1.7 | 0.02 |
   Diastolic BP, mmHg | 70.7 ± 3.4 | 74.7 ± 1.5 | 0.3 |
   Heart rate, beats/min | 89.3 ± 3.6 | 68.0 ± 1.6 | < 0.0001 |
Contributing causes to AKI, n (with urine KLK1 activity excretion, U/gm creatinine, mean ± SEM) |  |  | 0.83 |
   Ischemia | 7 (6.0 ± 3.7) | - | - |
   Nephrotoxins | 4 (7.2 ± 3.9) | - | - |
   Septic | 1 (4.6) | - | - |
   Multifactorial causes/other | 8 (7.6 ± 2.9) | - | - |