|
Characteristics
|
Established AKI patients (n = 20)
|
Healthy controls (n = 38)
|
P value*
|
|---|
|
Age, years
|
48.8 ± 3.5
|
46.3 ± 1.5
|
0.52
|
|
Sex (male/female), n
|
15/5
|
30/8
|
1
|
|
Ethnicity, n
| | |
0.6
|
|
White
|
11
|
20
| |
|
Black
|
3
|
6
| |
|
Hispanic
|
5
|
6
| |
|
Other
|
1
|
6
| |
|
Weight, kg
|
91.2 ± 6.2
|
93.9 ± 3.7
|
0.293
|
|
BMI, kg/m
2
|
31.1 ± 2.2
|
27.8 ± 1
|
0.177
|
|
Laboratory findings at enrollment
| | | |
|
sCr, mg/dl
|
2.7 ± 0.47
|
0.9 ± 0.04
|
0.0007
|
|
eGFR, ml/min
|
44.4 ± 7.5
|
97.5 ± 3.6
|
< 0.0001
|
|
uNa+/uCr, mEq/gm
|
127.6 ± 22.5
|
125.4 ± 9.4
|
0.347
|
|
uCr/sCr, ratio
|
42.4 ± 7.2
|
119.6 ± 11.4
|
< 0.0001
|
|
FeNa+, %
|
1.7 ± 0.4
|
0.8 ± 0.1
|
0.05
|
|
Vital signs at enrollment
| | | |
|
Systolic BP, mmHg
|
119.8 ± 4.4
|
131.4 ± 1.7
|
0.02
|
|
Diastolic BP, mmHg
|
70.7 ± 3.4
|
74.7 ± 1.5
|
0.3
|
|
Heart rate, beats/min
|
89.3 ± 3.6
|
68.0 ± 1.6
|
< 0.0001
|
|
Contributing causes to AKI, n (with urine KLK1 activity excretion, U/gm creatinine, mean ± SEM)
| | |
0.83
|
|
Ischemia
|
7 (6.0 ± 3.7)
|
-
|
-
|
|
Nephrotoxins
|
4 (7.2 ± 3.9)
|
-
|
-
|
|
Septic
|
1 (4.6)
|
-
|
-
|
|
Multifactorial causes/other
|
8 (7.6 ± 2.9)
|
-
|
-
|
- AKI = acute kidney injury, n = number of study subjects, BMI = body mass index, s = serum, u = urine, Cr = creatinine, FeNa+ = fractional excretion of sodium, SBP = systolic blood pressure, DBP = diastolic blood pressure, HR = heart rate, bpm = beats per minute, ICU = intensive care unit. *P values were calculated with Fisher's exact test for categorical variables, and ANOVA (log-transformed, adjusted for covariates: age, sex) for continuous variables. Plus-minus values are mean ± one SEM. Bold: p ≤ 0.05.
