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Table 3 Association of systolic and diastolic blood pressure with decline in renal function during the first year of pre-dialysis care

From: Association of blood pressure with decline in renal function and time until the start of renal replacement therapy in pre-dialysis patients: a cohort study

 

n

Baseline eGFR*

(ml/min/

1.73 m2)

Crude additional decline

(ml/min/

1.73 m2/month)

Adjusted additional decline

(ml/min/

1.73 m2/month)

Adjusted additional decline

(ml/min/

1.73 m2/month)

Systolic blood pressure (mmHg):

Per 10

436

 

0.03 (0.01;0.06)

0.04 (0.02;0.07)

0.04 (0.02;0.07)

   < 130

79

14.0

0§

0

0

130-149

116

12.8

0.13 (-0.09;0.34)

0.15 (-0.06;0.36)

0.14 (-0.07;0.35)

150-169

125

12.7

0.14 (-0.08;0.35)

0.19 (-0.02;0.39)

0.17 (-0.04;0.38)

170-189

72

14.2

0.19 (-0.05;0.43)

0.27 (0.04;0.51)

0.24 (0.00;0.48)

≥ 190

44

13.3

0.34 (0.06;0.61)

0.44 (0.16;0.71)

0.43 (0.15;0.70)

Diastolic blood pressure (mmHg):

Per 10

436

 

0.07 (0.02;0.12)

0.05 (0.00;0.10)

0.05 (0.00;0.11)

   < 80

122

13.4

0γ

0

0

80-89

151

13.7

0.08 (-0.10;0.26)

0.06 (-0.12;0.23)

0.07 (-0.11;0.25)

90-99

98

13.3

0.12 (-0.07;0.32)

0.12 (-0.08;0.31)

0.12 (-0.08;0.32)

≥ 100

65

11.9

0.29 (0.07;0.52)

0.23 (0.00;0.45)

0.22 (-0.01;0.44)

Blood pressure treatment target goal (mmHg):

< 130/< 80

47

14.2

0^

0

0

≥ 130/< 80

75

13.0

0.21 (-0.07;0.48)

0.31 (0.04;0.58)

0.31 (0.04;0.58)

< 130/≥ 80

32

13.8

0.22 (-0.12;0.55)

0.21 (-0.12;0.54)

0.26 (-0.08;0.59)

≥ 130/≥ 80

282

13.1

0.27 (0.04;0.50)

0.30 (0.08;0.53)

0.31 (0.08;0.53)

  1. The decline (95% confidence interval) presented for each blood pressure category indicates the additional decline in renal function compared to the reference category (systolic blood pressure (SBP) < 130 mmHg, diastolic blood pressure (DBP) < 80 mmHg, and SBP/DBP < 130/< 80 mmHg). A negative decline is equivalent to a slower decline in renal function.
  2. * The mean estimated glomerular filtration rate (eGFR) in ml/min/1.73 m2 at baseline. Adjusted for sex and age. Adjusted for sex, age, race, smoking, primary kidney disease, and the co-morbidities cardiovascular disease (CVD) and diabetes mellitus (DM). § The mean (standard deviation, SD) decline in renal function is 0.22 (0.74) ml/min/1.73 m2/month. γ The mean (SD) decline in renal function is 0.26 (0.90) ml/min/1.73 m2/month. ^The mean (SD) decline in renal function is 0.13 (0.85) ml/min/1.73 m2/month.