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Table 3 Association of systolic and diastolic blood pressure with decline in renal function during the first year of pre-dialysis care

From: Association of blood pressure with decline in renal function and time until the start of renal replacement therapy in pre-dialysis patients: a cohort study

  n Baseline eGFR*
(ml/min/
1.73 m2)
Crude additional decline
(ml/min/
1.73 m2/month)
Adjusted additional decline
(ml/min/
1.73 m2/month)
Adjusted additional decline
(ml/min/
1.73 m2/month)
Systolic blood pressure (mmHg):
Per 10 436   0.03 (0.01;0.06) 0.04 (0.02;0.07) 0.04 (0.02;0.07)
   < 130 79 14.0 0§ 0 0
130-149 116 12.8 0.13 (-0.09;0.34) 0.15 (-0.06;0.36) 0.14 (-0.07;0.35)
150-169 125 12.7 0.14 (-0.08;0.35) 0.19 (-0.02;0.39) 0.17 (-0.04;0.38)
170-189 72 14.2 0.19 (-0.05;0.43) 0.27 (0.04;0.51) 0.24 (0.00;0.48)
≥ 190 44 13.3 0.34 (0.06;0.61) 0.44 (0.16;0.71) 0.43 (0.15;0.70)
Diastolic blood pressure (mmHg):
Per 10 436   0.07 (0.02;0.12) 0.05 (0.00;0.10) 0.05 (0.00;0.11)
   < 80 122 13.4 0γ 0 0
80-89 151 13.7 0.08 (-0.10;0.26) 0.06 (-0.12;0.23) 0.07 (-0.11;0.25)
90-99 98 13.3 0.12 (-0.07;0.32) 0.12 (-0.08;0.31) 0.12 (-0.08;0.32)
≥ 100 65 11.9 0.29 (0.07;0.52) 0.23 (0.00;0.45) 0.22 (-0.01;0.44)
Blood pressure treatment target goal (mmHg):
< 130/< 80 47 14.2 0^ 0 0
≥ 130/< 80 75 13.0 0.21 (-0.07;0.48) 0.31 (0.04;0.58) 0.31 (0.04;0.58)
< 130/≥ 80 32 13.8 0.22 (-0.12;0.55) 0.21 (-0.12;0.54) 0.26 (-0.08;0.59)
≥ 130/≥ 80 282 13.1 0.27 (0.04;0.50) 0.30 (0.08;0.53) 0.31 (0.08;0.53)
  1. The decline (95% confidence interval) presented for each blood pressure category indicates the additional decline in renal function compared to the reference category (systolic blood pressure (SBP) < 130 mmHg, diastolic blood pressure (DBP) < 80 mmHg, and SBP/DBP < 130/< 80 mmHg). A negative decline is equivalent to a slower decline in renal function.
  2. * The mean estimated glomerular filtration rate (eGFR) in ml/min/1.73 m2 at baseline. Adjusted for sex and age. Adjusted for sex, age, race, smoking, primary kidney disease, and the co-morbidities cardiovascular disease (CVD) and diabetes mellitus (DM). § The mean (standard deviation, SD) decline in renal function is 0.22 (0.74) ml/min/1.73 m2/month. γ The mean (SD) decline in renal function is 0.26 (0.90) ml/min/1.73 m2/month. ^The mean (SD) decline in renal function is 0.13 (0.85) ml/min/1.73 m2/month.