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Table 4 Association of systolic and diastolic blood pressure with time until the start of renal replacement therapy during the first year of pre-dialysis care

From: Association of blood pressure with decline in renal function and time until the start of renal replacement therapy in pre-dialysis patients: a cohort study

  Events/n Crude HR Adjusted HR Adjusted HR
Systolic blood pressure (mmHg):
Per 10 235/508 1.08 (1.03;1.13) 1.09 (1.04;1.14) 1.09 (1.04;1.14)
   < 130 29/91 1 1 1
130-149 60/136 1.52 (0.97;2.36) 1.54 (0.99;2.41) 1.60 (1.02;2.50)
150-169 74/147 1.82 (1.19;2.80) 1.88 (1.22;2.90) 1.96 (1.27;3.02)
170-189 46/83 2.09 (1.31;3.32) 2.20 (1.37;3.53) 2.25 (1.40;3.63)
   ≥ 190 26/51 2.10 (1.24;3.57) 2.27 (1.33;3.90) 2.21 (1.28;3.80)
Diastolic blood pressure (mmHg):
Per 10 235/508 1.15 (1.04;1.27) 1.15 (1.04;1.27) 1.16 (1.05;1.28)
   < 80 63/153 1 1 1
80-89 76/174 1.02 (0.73;1.43) 1.03 (0.74;1.44) 1.05 (0.75;1.48)
90-99 49/106 1.09 (0.75;1.58) 1.11 (0.76;1.62) 1.11 (0.76;1.62)
≥ 100 47/75 1.84 (1.26;2.69) 1.85 (1.26;2.71) 1.88 (1.27;2.78)
Blood pressure treatment target goal (mmHg):
< 130/< 80 17/58 1 1 1
≥ 130/< 80 46/95 1.93 (1.11;3.37) 2.03 (1.15;3.57) 2.24 (1.26;3.97)
< 130/≥ 80 12/33 1.18 (0.56;2.47) 1.18 (0.56;2.47) 1.31 (0.62;2.78)
≥ 130/≥ 80 160/322 1.91 (1.16;3.16) 1.96 (1.19;3.23) 2.08 (1.25;3.44)
  1. The hazard ratio (HR) (95% confidence interval, CI) presented for each blood pressure category indicates the increased risk of starting renal replacement therapy (RRT) compared to the reference category (systolic blood pressure (SBP) < 130 mmHg, diastolic blood pressure (DBP) < 80 mmHg, and SBP/DBP < 130/< 80 mmHg).
  2. Adjusted for sex and age. Adjusted for sex, age, race, smoking, primary kidney disease, and the co-morbidities cardiovascular disease (CVD) and diabetes mellitus (DM).