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Table 5 Hazard ratio of recurrent cardiovascular event or death in ADVANCE cohort by eGFR (ml/min/1.73 m2)*

From: Potential role of differential medication use in explaining excess risk of cardiovascular events and death associated with chronic kidney disease: A cohort study

 

Hazard ratio (95% CI) of recurrent cardiovascular event or death

Model 1: Unadjusted Model

 

eGFR > 60

Referent

eGFR 45-59

1.61 (1.18 to 2.18)

eGFR < 45

1.85 (1.19 to 2.89)

Model 2: Adjusted for age, sex, race/ethnicity, smoking, alcohol use, and physical activity

 

eGFR > 60

Referent

eGFR 45-59

1.52 (1.11 to 2.10)

eGFR < 45

1.70 (1.10 to 2.67)

Model 3: Model 2 + adjusted for body mass index and history of diabetes and hypertension

 

eGFR > 60

Referent

eGFR 45-59

1.47 (1.10 to 2.02)

eGFR < 45

1.58 (1.00 to 2.50)

Model 4: Model 3 + medication possession ratio of statins, β-blockers, calcium channel blockers, ACE inhibitors † /ARBs ‡

 

eGFR > 60

Referent

eGFR 45-59

0.82 (0.25 to 2.66)

eGFR < 45

1.19 (0.25 to 5.58)

  1. *eGFR indicates glomerular filtration rate
  2. †ACE inhibitor indicates angiotensin converting enzyme inhibitor
  3. ‡ARB indicates angiotensin receptor blocker