Table 1 Baseline Characteristics of the Three Age Cohorts at Time of Transplantation
From: Kidney transplant survival in pediatric and young adults
Pediatric PED N = 56 | Young Adult YAD N = 54 | Adult ADL N = 137 | p-value | |
|---|---|---|---|---|
Age years | 11 ± 5 | 21 ± 2 | 30 ± 3 | < 0.001 |
Gender male | 29 (52%) | 31 (57%) | 79 (58%) | 0.75 |
Deceased Donor | 31 (55%) | 23 (43%) | 74 (54%) | 0.34 |
Donor Age years | 36 ± 12 | 37 ± 14 | 36 ± 15 | 0.99 |
Pre-emptive | 18 (32%) | 15 (28%) | 33 (24%) | 0.51 |
1st graft | 42 (80%) | 45 (83%) | 103 (75%) | 0.44 |
CMV D+/R- | 12 (21%) | 11 (20%) | 29 (21%) | 0.98 |
HLA Mismatch | 3.5 ± 1.1 | 3.7 ± 1.4 | 3.8 ± 1.4 | 0.35 |
Delayed Graft Function | 8 (14%) | 5 (9%) | 18 (13%) | 0.69 |
Peak PRA % | 4 ± 15 | 5 ± 15 | 4 ± 10 | 0.88 |
Diabetes Mellitus | 0 | 4 (8%) | 20 (18%) | 0.007 |
Rejection within Year 1 | 22 (39%) | 16 (30%) | 41 (30%) | 0.41 |
Year of Transplant | ||||
1990-1994 | 13 (23%) | 22 (41%) | 45 (33%) | 0.055 |
1995-1999 | 18 (32%) | 9 (17%) | 42 (31%) | |
2000-2004 | 14 (25%) | 11 (20%) | 30 (21%) | |
2005-2009 | 11 (20%) | 12 (22%) | 20 (14%) | |
Immunosuppression | ||||
Individual | 25 (45%) | 5 (9.3%) | 34 (25%) | < 0.001 |
Depleting Antibody | 50 (89%) | 38 (70%) | 94 (69%) | < 0.001 |
Cyclosporine (CSA) | 4 (7%) | 16 (30%) | 43 (31%) | < 0.001 |
Tacrolimus (TAC) | 40 (71%) | 22 (41%) | 50 (36%) | < 0.001 |
Azathioprine (AZA) | 13 (23%) | 29 (54%) | 75 (55%) | < 0.001 |
Mycophenolate (MPA) | ||||
Immunosuppression | ||||
Combinations | 45 (80%) | 21 (39%) | 49 (36%) | < 0.001 |
CSA/AZA | 10 (18%) | 17 (31%) | 35 (26%) | |
CSA/MPA | 0 | 1 (1.8%) | 1 (0.7%) | |
TAC/AZA | 4 (7%) | 12 (22%) | 41 (30%) | |
TAC/MMF | 1 (1.8%) | 3 (5.5%) | 11 (8%) | |
Other |