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Table 3 Oxidative stress, serum cytokines, serum nitrites and nitrates during albumin and gelatin infusions

From: Modulation of oxidative stress and microinflammatory status by colloids in refractory dialytic hypotension

Parameter

Before treatment

Albumin infusion period

Wah-Out period

Gelatin infusion period

Statistical analyses

Plasma total anti-oxydant power (copper reducing equivalent microM)

0.23 ± 0.08

0.26 ± 0.11

0.27 ± 0.13

0.22 ± 0.11

p > 0.05 at the repeated measures ANOVA

Hydrogen peroxyde μg/ml

29.97 ± 7.3

10.87 ± 1.9

14.57 ± 2.5

11.19 ± 2.4

p < 0.001 at the repeated measures ANOVA

Lipid peroxides (H202 equivalent) μM/1

50 [13.84-189.5]

7 [7-209.4]

37.30 [7-305]

38.20 [7.82-298.7]

p < 0.005 at the Friedman test

Lactoferrin at the beginning of the dialysis session (ng/ml)

245.7 ± 154

199.3 ± 133

154 ± 36.98

153.7 ± 29.79

p > 0.05 at the repeated measures ANOVA

Lactoferrin at the end of the dialysis session (ng/ml)

159.7 ± 40.52

144.5 ± 48

152.8 ± 31.42

154.9 ± 74.31

p > 0.05 at the repeated measures ANOVA

IL6 at the beginning of the dialysis session (pg/ml)

5.55 ± 8.19

2.44 ± 2.82

2.19 ± 2.87

1.74 ± 2.51

p > 0.05 at the repeated measures ANOVA

IL6 at the end of the dialysis session (pg/ml)

6.88 ± 7.56

6 ± 3.98

4.26 ± 2.19

5 ± 3.4

p > 0.05 at the repeated measures ANOVA

IL8 at the beginning of the dialysis session (pg/ml)

32.77 ± 43.79

21 ± 9.89

24 ± 18

19.83 ± 13.89

p > 0.05 at the Friedman test

TNF α at the beginning of the dialysis session pg/ml

9.85 ± 10.82

9.13 ± 5.87

8.04 ± 10.22

4.72 ± 3.59

p > 0.05 at the repeated measures ANOVA

TNF α at the end of the dialysis session pg/ml

8.33 ± 7.17

7.59 ± 4.67

5.40 ± 2.82

4.51 ± 2.96

p > 0.05 at the repeated measures ANOVA

Serum nitrates + nitrites at the beginning of the dialysis session (μmol/1)

49 ± 24.90

50.35 ± 30.87

53.66 ± 26

55.35 ± 28.42

p > 0.05 at the repeated measures ANOVA

Serum nitrates + nitrites at the end of the dialysis session (μmol/I)

45.34 ± 27.16

48.58 ± 17.78

47.27 ± 20

53.70 ± 34.48

p > 0.05 at the repeated measures ANOVA

  1. The values are given either as mean ± SD in case of gaussian distribution or as medium [range] in case of non parametric distribution