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Table 3 Median adipokine levels among participants treated with high-dose and usual-dose ESA and unadjusted and adjusted odds of adipokine being below the median

From: Association between high-dose erythropoiesis-stimulating agents, inflammatory biomarkers, and soluble erythropoietin receptors

Variable

High-dose ESA

(≥1 mcg/kg/wk of

darbepoetin-α)

(n = 11)

Usual-Dose ESA

(< 1 mcg/kg/wk of

darbepoetin-α)

(n = 21)

Unadjusted Odds Ratio, *

(5-95% CI)

p-value

Adjusted Odds Ratio, * (5-95% CI)

p-value

Adiponectin (ng/ml)

18718.6 (13328.6, 33469.4)

15397.4 (8032.5, 53063.7)

0.76 (0.2-3.3)

p = 0.7

7.8 (0.5-109.2)

p = 0.1

Leptin (ng/ml)

30.9 (1.5, 102.6)

43.4 (9.8, 82.6)

2.33 (0.5-10.5)

p = 0.3

1.7 (0.1-19.2)

p = 0.7

  1. *Odds of cytokine being below the median among those in high vs usual dose ESA,
  2. **Adjusted for gender, hemoglobin, and weight