Figure 5

Doxycycline inhibits MT1-MMP, MMP9 and MMP2 expression in polycystic kidneys of PCK rats. Immunohistochemical staining (brown color) of vehicle-treated (A, C, E) and doxycycline-treated kidneys (B, D, F) of PCK rats with antibodies against MT1-MMP, MMP9, and MMP2, respectively (Scale bars: 50 μm).