Postdialysis blood pressure rise predicts long-term outcomes in chronic hemodialysis patients: a four-year prospective observational cohort study

Yang, Chih-Yu; Yang, Wu-Chang; Lin, Yao-Ping

doi:10.1186/1471-2369-13-12

Table 2 Univariate and multivariate Cox regression analysis of significant predictors of 4-year all-cause mortality in hemodialysis patients

From: Postdialysis blood pressure rise predicts long-term outcomes in chronic hemodialysis patients: a four-year prospective observational cohort study

Factor	Univariate				Multivariate
	HR	95% CI		p Value	HR	95% CI		p Value
		Lower	Upper			Lower	Upper
Age (10 year)	1.713	1.284	2.286	< 0.001*	1.947	1.366	2.775	< 0.001
Male gender (%)	1.899	1.014	3.557	0.045*	4.267	1.985	9.171	< 0.001
Dialysis duration (year)	0.951	0.889	1.017	0.140
Body mass index (Kg/m²)	1.000	0.914	1.093	0.995
Smoking index	1.167	0.795	1.712	0.430
Kt/V	0.116	0.033	0.416	0.001*
Comorbidities (%)
Diabetes mellitus (%)	2.125	1.138	3.967	0.018*
Hypertension (%)	1.352	0.417	4.388	0.615
Cardiovascular disease (%)	2.256	1.204	4.227	0.011*
Prior stroke (%)	2.588	0.797	8.406	0.114
Malignancy (%)	2.704	1.130	6.467	0.025*
Hepatitis B infection (%)	0.887	0.273	2.879	0.842
Hepatitis C infection (%)	0.896	0.376	2.135	0.805
Medications
Antihypertensive agents (%)	0.921	0.439	1.935	0.829
ACE inhibitor/ARB (%)	1.141	0.614	2.121	0.676
Vitamin D₃ (%)	1.156	0.533	2.510	0.713
Laboratory data
Albumin (g/dL)	0.136	0.044	0.425	0.001*	0.032	0.008	0.126	< 0.001
Total cholesterol (mg/dL)	0.997	0.989	1.006	0.509
Triglycerides (mg/dL)	1.001	0.999	1.003	0.442
Sodium (mmol/L)	0.937	0.841	1.044	0.236
Chloride (mmol/L)	0.984	0.869	1.114	0.801
Bicarbonate (mmol/L)	0.959	0.851	1.082	0.497
ALT (U/L)	1.001	0.978	1.024	0.963
Alk-P (mg/dL)	1.000	0.995	1.005	0.927
Fasting glucose (mg/dL)	1.004	1.000	1.008	0.030*
HbA_1c (%)	1.135	0.956	1.347	0.149
WBC count (1000 per cumm)	0.958	0.788	1.166	0.671
Hemoglobin (g/dL)	1.019	0.806	1.289	0.873
High-sensitive CRP (mg/dL)	1.432	1.062	1.932	0.019*	1.534	1.072	2.195	0.019
Ferritin (ng/mL)	1.000	1.000	1.001	0.743
Transferrin saturation (%)	0.826	0.065	10.479	0.883
Peridialytic BP
predialytic SBP (mmHg)	1.000	0.980	1.020	0.993
postdialytic SBP (mmHg)	1.008	0.990	1.026	0.393
predialytic MAP (mmHg)	0.992	0.959	1.027	0.648
postdialytic MAP (mmHg)	1.003	0.970	1.038	0.844
predialytic DBP (mmHg)	0.978	0.934	1.024	0.346
postdialytic DBP (mmHg)	0.981	0.932	1.032	0.452
predialytic PP (mmHg)	1.008	0.981	1.035	0.578
postdialytic PP (mmHg)	1.016	0.994	1.038	0.159
Peridialytic BP alterations (no as reference)
postdialytic SBP rise > 5 mmHg (yes/no)	2.382	1.280	4.434	0.006*	3.925	1.420	10.846	0.008
postdialytic MAP rise > 5 mmHg (yes/no)	1.762	0.929	3.344	0.083
postdialytic DBP rise > 5 mmHg (yes/no)	1.602	0.800	3.207	0.184
postdialytic PP rise > 5 mmHg (yes/no)	1.548	0.808	2.965	0.188
Ultrafiltration volume (Kg)	1.355	0.944	1.944	0.099*	3.470	2.045	5.889	< 0.001
CT ratio > 50% (yes/no)	8.960	2.322	34.572	0.001*	7.560	2.048	27.912	0.002

Abbreviations: HR, Hazard ratio; CI, confidence interval; ACE, angiotensin converting enzyme; ARB, angiotensin II-receptor blocker; ALT, alanine aminotransferase; Alk-P, alkaline phosphatase; HbA1c, glycosylated hemoglobin; WBC, white blood cell; CRP, C-reactive protein; BP, blood pressure; SBP, systolic blood pressure; MAP, mean arterial pressure; DBP, diastolic blood pressure; PP, pulse pressure; CT, cardiothoracic. *Variables further included in the multivariate Cox regression analysis.

Back to article page

ISSN: 1471-2369

Contact us

Submission enquiries: bmcnephrology@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Nephrology

Contact us