Picking transplant glomerulopathy out of the CAN: evidence from a clinico-pathological evaluation

BMC Nephrology

Table 3 Pathologic features of the TG and non-TG groups*

Pathology features	TG (n = 43)	non-TG (n = 43)	P value
TG score	1.88 ± 0.85	0.0 ± 0.0	<0.0001
C4d+	30 (69.8%)	14 (32.6%)	0.001
C4d score	1.91 ± 1.32	0.58 ± 0.96	<0.0001
Peritubular capillaritis present	40 (93.0%)	15 (34.9%)	<0.0001
PTC score	1.88 ± 0.79	0.49 ± 0.73	<0.0001
Glomerulitis present	40 (93.0%)	27 (62.8%)	0.001
Glomerulitis score	1.35 ± 0.69	0.79 ± 0.74	<0.001
Mesangial matrix expansion score	1.58 ± 0.62	1.07 ± 0.63	<0.001
Interstitial fibrosis (ci)	1.51 ± 0.83	1.33 ± 0.72	0.27
Tubular atrophy (ct)	1.49 ± 0.88	1.47 ± 0.77	0.89
Fibrous intimal thickening (cv)	1.14 ± 0.83	0.91 ± 0.68	0.16
IgA stain positive(%)	19 (44.2%)	7 (16.3%)	0.005
IgA score	0.70 ± 0.86	0.26 ± 0.62	0.008
CD4 cell infiltration in glomerular	0.82 ± 0.84	0.31 ± 0.53	0.002
CD8 cell infiltration in glomerular	0.86 ± 1.15	0.49 ± 0.90	0.127
CD68 cell infiltration in glomerular	7.84 ± 6.19	1.64 ± 2.98	<0.001

Data are presented as mean ± SD or number of cases. *Evaluation of the biopsies was based on the Banff ’07 acute and chronic indices, including presence of glomerulitis, TG, mesangial matrix expansion (based on silver stain), degree of PTC congestion, extent of interstitial fibrosis (based on trichrome stain) and tubular atrophy, vascular pathology, and deposition of C4d.

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