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Table 4 Cox model measured hazard ratios and 95% confidence intervals of dementia associated with CKD and covariates

From: Patients with chronic kidney disease are at an elevated risk of dementia: A population-based cohort study in Taiwan

 

Crude

Adjusted

Variable

HR

(95%CI)

HR

(95%CI)

Sex

Women

1.00

 

1.00

 

Men

0.94

(0.89-1.00)

0.97

(0.92-1.03)

Age, years

20–39

1.00

 

1.00

 

40–64

19.7

(10.2-38.0)

16.1

(8.35-31.2)

≥65

216

(112.-414)

133

(68.9-256)

CKD

No

1.00

 

1.00

 

Yes

1.68

(1.58-1.78)

1.41

(1.32-1.50)

Hypertension

No

1.00

 

1.00

 

Yes

4.10

(3.85-4.37)

1.17

(1.09-1.26)

Diabetes mellitus

No

1.00

 

1.00

 

Yes

2.14

(2.00-2.28)

1.25

(1.17-1.34)

Ischemic heart disease

No

1.00

 

1.00

 

Yes

3.11

(2.94-3.30)

1.00

(0.93-1.06)

Hyperlipidemia

No

1.00

 

1.00

 

Yes

1.35

(1.25-1.45)

0.89

(0.83-0.97)

Tobacco use disorder

No

1.00

 

1.00

 

Yes

1.00

(0.48-2.09)

--

 

Alcoholism

No

1.00

 

1.00

 

Yes

1.78

(1.27-2.49)

3.05

(2.17-4.28)

Obesity

No

1.00

 

1.00

 

Yes

0.64

(0.41-1.00)

0.93

(0.59-1.46)

Atrial fibrillation

No

1.00

 

1.00

 

Yes

3.77

(3.19-4.45)

1.17

(0.99-1.39)

Parkinson's disease

No

1.00

 

1.00

 

Yes

6.92

(6.13-7.82)

1.80

(1.59-2.04)

Cerebrovascular disease

No

1.00

 

1.00

 

Yes

4.85

(4.57-5.14)

1.72

(1.61-1.84)

Major depressive disorder

No

1.00

 

1.00

 

Yes

2.68

(2.26-3.17)

1.95

(1.64-2.31)

Use of benzodiazepine

No

1.00

 

1.00

 

Yes

2.54

(2.37-2.71)

1.23

(1.14-1.32)

Use of aspirin

No

1.00

 

1.00

 

Yes

1.85

(1.71-2.00)

1.02

(0.95-1.11)

Use of other NSAIDs

No

1.00

 

1.00

 

Yes

1.54

(1.39-1.70)

1.01

(0.91-1.12)

Use of COX2

No

1.00

 

1.00

 

Yes

2.45

(2.31-2.60)

1.09

(1.02-1.16)

  1. Adjusted for sex, age, CKD, hypertension, diabetes mellitus, ischemic heart disease, hyperlipidemia, alcoholism, obesity, atrial fibrillation, Parkinson's disease, cerebrovascular disease, major depressive disorder, use of benzodiazepine, aspirin, other NSAIDs and COX2.