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Table 4 Cox model measured hazard ratios and 95% confidence intervals of dementia associated with CKD and covariates

From: Patients with chronic kidney disease are at an elevated risk of dementia: A population-based cohort study in Taiwan

  Crude Adjusted
Variable HR (95%CI) HR (95%CI)
Sex
Women 1.00   1.00  
Men 0.94 (0.89-1.00) 0.97 (0.92-1.03)
Age, years
20–39 1.00   1.00  
40–64 19.7 (10.2-38.0) 16.1 (8.35-31.2)
≥65 216 (112.-414) 133 (68.9-256)
CKD
No 1.00   1.00  
Yes 1.68 (1.58-1.78) 1.41 (1.32-1.50)
Hypertension
No 1.00   1.00  
Yes 4.10 (3.85-4.37) 1.17 (1.09-1.26)
Diabetes mellitus
No 1.00   1.00  
Yes 2.14 (2.00-2.28) 1.25 (1.17-1.34)
Ischemic heart disease
No 1.00   1.00  
Yes 3.11 (2.94-3.30) 1.00 (0.93-1.06)
Hyperlipidemia
No 1.00   1.00  
Yes 1.35 (1.25-1.45) 0.89 (0.83-0.97)
Tobacco use disorder
No 1.00   1.00  
Yes 1.00 (0.48-2.09) --  
Alcoholism
No 1.00   1.00  
Yes 1.78 (1.27-2.49) 3.05 (2.17-4.28)
Obesity
No 1.00   1.00  
Yes 0.64 (0.41-1.00) 0.93 (0.59-1.46)
Atrial fibrillation
No 1.00   1.00  
Yes 3.77 (3.19-4.45) 1.17 (0.99-1.39)
Parkinson's disease
No 1.00   1.00  
Yes 6.92 (6.13-7.82) 1.80 (1.59-2.04)
Cerebrovascular disease
No 1.00   1.00  
Yes 4.85 (4.57-5.14) 1.72 (1.61-1.84)
Major depressive disorder
No 1.00   1.00  
Yes 2.68 (2.26-3.17) 1.95 (1.64-2.31)
Use of benzodiazepine
No 1.00   1.00  
Yes 2.54 (2.37-2.71) 1.23 (1.14-1.32)
Use of aspirin
No 1.00   1.00  
Yes 1.85 (1.71-2.00) 1.02 (0.95-1.11)
Use of other NSAIDs
No 1.00   1.00  
Yes 1.54 (1.39-1.70) 1.01 (0.91-1.12)
Use of COX2
No 1.00   1.00  
Yes 2.45 (2.31-2.60) 1.09 (1.02-1.16)
  1. Adjusted for sex, age, CKD, hypertension, diabetes mellitus, ischemic heart disease, hyperlipidemia, alcoholism, obesity, atrial fibrillation, Parkinson's disease, cerebrovascular disease, major depressive disorder, use of benzodiazepine, aspirin, other NSAIDs and COX2.