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Table 2 Changes in the plasma levels of the investigated cellular hypoxia and oxidative stress biomarkers in studied groups

From: Hypoxia and oxidative stress markers in pediatric patients undergoing hemodialysis: cross section study

Parameters Controls (n = 20) Before dialysis (n = 40) After dialysis (n = 40)
Total antioxidant capacity (mmol/L) 0.66 ± 0.05 0.60 ± 0.05 0.57 ± 0.06
  * P <0.001 * P <0.001
** P <0.036
Total peroxides (μmol/L) 30.50 ± 12.76 38.50 ± 12.52 37.25 ± 12.92
  * P <0.021 * P <0.050
**P = 0.673
Oxidative stress index 4.63 ± 1.89 6.52 ± 2.30 6.53 ± 2.23
  * P <0.002 * P <0.002
**P = 0.983
Lactate (mg/dL) 12.06 ± 3.66 15.90 ± 6.56 13.34 ± 5.99
  * P <0.019 *P = 0.425
**P = 0.061
Pyruvate (mg/dL) 5.02 ± 3.67 6.47 ± 8.69 6.84 ± 4.02
  *P = 0.402 *P = 0.280
**P = 0.777
Lactate/pyruvate ratio 3.36 ± 1.69 4.07 ± 2.70 2.57 ± 1.76
  *P = 0.234 *P = 0.187
** P <0.007
Vascular endothelial growth factor (pg/mL) 4.00 ± 1.26 32.91 ± 24.40 33.15±24.58
  * P <0.001 * P <0.001
**P =0.964
Hypoxia-induced factor- 1α (pg/mL) 29.45 ± 10.07 57.02 ± 41.86 43.29 ± 26.67
  * P <0.002 *P = 0.115
**P = 0.120
  1. Data shown are mean ± SD mean -/+ SD (minimum - maximum); *P: significance vs. healthy controls; **P: significance vs. before-dialysis session.