Figure 2

The renal histology in wild-type and acatalasemic mice. Light micrographs of a glomerulus of wild-type (A, C and E) and acatalasemic (B, D and F) glomeruli at 0, 4 and 8 weeks after adriamycin (ADR) administration are shown. The week 0 glomeruli were microscopically normal. Note that the segmental sclerosis is significant in both acatalasemic and wild-type glomeruli at the later time points. The glomerular area (G) and sclerosis index (H) of wild-type (open bars) or acatalasemic (closed bars) mice are also shown. A through F: periodic acid-Schiff stain. Scale bars: 20 μm (A through F). G and H: Each column shows the means ± SE. N = 6 to 15 animals/group. *: P < 0.05 vs. wild-type ADR mice at the same time point. #: p < 0.05 vs. week 0 in the same group. ##: p < 0.01 vs. week 0 in the same group.