Figure 3

Light micrographs of the wild-type ( A, C and E ) and acatalasemic ( B, D and F ) kidney cortex at 0, 4 and 8 weeks after adriamycin (ADR) administration are shown. Note that interstitial fibrosis significantly developed in the kidneys of the acatalasemic mice. The fibrosis scores (G) and cast scores (H) of wild-type (open bars) and acatalasemic (closed bars) mice are also shown. A through F: Masson's trichrome stain. Scale bars: 200 μm (A through F). G and H: Each column includes the means ± SE. N = 6 to 15 animals/group. #: p < 0.05 vs. week 0 in the same group. ##: p < 0.01 vs. week 0 in the same group.