Figure 4

Immunohistochemical staining of 4-hydroxy-2-nonenal (4-HNE). Wild-type (A, C and E) and acatalasemic (B, D and F) cortex samples at 0, 4 and 8 weeks after adriamycin (ADR) administration are shown. The 4-HNE positive areas (G) of wild-type (open bars) or acatalasemic (closed bars) mice are also shown. Scale bars: 50 μm (A through F). G: Each column shows the means ± SE. N = 6 to 8 animals/group. **: P < 0.01 vs. wild-type ADR mice at the same time point. ##: p < 0.01 vs. week 0 in the same group.