Table 1 List of the CUBN SNPs in the extended European Haplotype, including the reported albuminuria risk variant p.Ile2984Val[8]and two other missense mutations (p.Leu2153Phe and p.Glu3002Gly)
Marker ID | Variation Type | Allele Frequency YRI (%)1 | Allele Frequency CEU (%)1 | LD with the reported Ile2984Val Variant in CEU population1 | Distance from the reported Ile2984Val Variant (bp) | ||
|---|---|---|---|---|---|---|---|
r^2 | LOD | D’ | |||||
rs1801240 | Glu3002Gly | 21.1 | 6.7 | 1.00 | 10.36 | 1 | −55 |
rs1801239 | Ile2984Val | 0 2 | 6.7 2 | -- | -- | -- | 0 |
rs74440730 | Intronic | 2.5 | 5.8 | 0.87 | 8.17 | 1 | 1,840 |
rs79051478 | Intronic | 0 | 6.7 | 1.00 | 10.36 | 1 | 5,557 |
rs78936062 | Intronic | 1.7 | 6.7 | 1.00 | 10.36 | 1 | 8,825 |
rs74942409 | Intronic | 0 | 6.7 | 1.00 | 10.36 | 1 | 9,249 |
rs17343073 | Intronic | 0 | 6.7 | 1.00 | 10.36 | 1 | 13,144 |
rs78625146 | Intronic | 0 | 6.7 | 1.00 | 10.36 | 1 | 14,787 |
rs79801018 | Intronic | 9.3 | 6.7 | 1.00 | 10.36 | 1 | 18,607 |
rs78786782 | Intronic | 9.3 | 6.7 | 1.00 | 10.36 | 1 | 18,723 |
rs73592376 | Intronic | 50.8 | 6.7 | 1.00 | 10.36 | 1 | 18,735 |
rs77744173 | Intronic | 0 | 6.7 | 1.00 | 10.36 | 1 | 19,219 |
rs45619139 | Intronic | 0 | 6.7 | 1.00 | 10.36 | 1 | 21,794 |
rs74375025 | Intronic | 0 | 6.7 | 1.00 | 10.36 | 1 | 28,612 |
rs45487598 | Intronic | 0 | 8.3 | 0.79 | 8.18 | 1 | 39,601 |
17006102-Indel 3 | Intronic indel | 15.9 | 7.1 | 0.88 | 8.99 | 1 | 47,044 |
17006421-Indel 3 | Intronic indel | 15.1 | 7.1 | 0.88 | 8.99 | 1 | 45,523 |
rs62619939 | Leu2153Phe | 15.3 | 8.3 | 0.79 | 8.18 | 1 | 48,534 |
rs111263197 | Intronic | 17.8 | 8.3 | 0.79 | 8.18 | 1 | 49,490 |