Table 5 Effects of hypertonic saline infusion (3%, 7 ml kg^-1) on PRC, Ang II, Aldo, ANP, BNP, and AVP in 21 patients with essential hypertension and 20 normotensive controls during high and low sodium intake

PRC (mU l ^-1 )

HS

Patients

4.8 (2.9; 6.7)§

3.8 (2.5; 5.1)†

3.5 (2.0; 5.1)

4.2 (2.1; 6.3)

P = 0.311

Controls

6.5 (3.1; 9.8)§

4.4 (3.0; 5.7)

4.8 (2.4; 7.2)

5.5 (2.5; 8.6)

LS

Patients

13.6 (8.5; 18.8)

8.9 (5.8; 12.0)

6.6 (4.7; 8.4)†

8.2 (4.8; 11.6)

P = 0.145

Controls

19.8 (13.5; 26.0)

11.1 (8.2; 14.0)†

11.5 (4.7; 18.3)

11.2 (4.5; 17.8)

AngII (pmol l ^-1 )

HS

Patients

4.0 (3.2; 4.7)*§

3.4 (2.3; 4.5)

3.5 (2.3; 4.7)

3.4 (2.4; 4.3)

P = 0.079

Controls

6.1 (4.4; 7.8)§

4.6 (2.8; 6.4)

4.4 (3.4; 5.4)

4.2 (3.1; 5.2)

LS

Patients

11.7 (7.3; 16.0)

6.4 (4.5; 8.3)†

5.6 (4.5; 6.7)†

5.7 (4.1; 7.3)†

P = 0.080

Controls

14.4 (11.1; 17.6)

9.3 (5.6; 12.9)†

8.8 (6.2; 11.3)†

7.7 (5.8; 9.6)†

Aldo (pmol l ^-1 )

HS

Patients

227 (192; 261)§

173 (147; 199)†

168 (144; 192)†

175 (152; 199)†

P = 0.063

Controls

188 (154; 221)§

145 (123; 166)†

137 (120; 155)†

151 (131; 170)

LS

Patients

352 (275; 428)

237 (196; 279)†

214 (185; 244)†

231 (202; 260)†

P = 0.973

Controls

365 (296; 434)

238 (193; 284)†

211 (178; 244)†

216 (188; 245)†

ANP (pmol l ^-1 )

HS

Patients

11.7 (9.6; 13.9)§

16.3 (12.5; 20.1)

14.4 (11.5; 17.4)†

12.8 (10.2; 15.4)†

P = 0.415

Controls

11.1 (9.5; 12.7)§

14.4 (12.1; 16.7)

12.9 (11.1; 14.8)†

11.6 (9.9; 13.3)†

LS

Patients

7.4 (5.9; 8.8)

11.1 (8.6; 13.7)†

10.1 (7.8; 12.4)†

9.1 (7.2; 11.0)†

P = 0.707

Controls

7.3 (5.8; 8.8)

10.4 (8.7; 12.0)†

9.5 (7.9; 11.0)†

8.9 (7.3; 10.4)†

BNP (pmol l ^-1 )

HS

Patients

2.2 (0.8; 3.7)§

2.6 (0.9; 4.2)

2.4 (1.1; 3.8)†

2.5 (1.1; 3.8)

P = 0.938

Controls

2.2 (0.5; 3.9)§

2.5 (0.6; 4.4)

2.6 (0.5; 4.7)

2.7 (0.5; 4.9)

LS

Patients

0.9 (0.6; 1.2)

1.0 (0.6; 1.4)

1.1 (0.7; 1.4)

1.1 (0.7; 1.5)

P = 0.941

Controls

1.0 (0.4; 1.5)

1.0 (0.5; 1.6)

1.1 (0.5; 1.7)

1.1 (0.5; 1.7)†

AVP (pg ml ^-1 )

HS

Patients

0.69 (0.60; 0.77)

1.08 (0.91; 1.24)†

0.87 (0.75; 0.99)†

0.70 (0.60; 0.79)

P = 0.520

Controls

0.66 (0.57; 0.75)

0.97 (0.82; 1.12)†

0.79 (0.66; 0.92)†

0.72 (0.60; 0.83)

LS

Patients

0.65 (0.57; 0.73)

1.04 (0.88; 1.19)†

0.86 (0.75; 0.96)†

0.73 (0.64; 0.83)

P = 0.535

Controls

0.66 (0.57; 0.75)

0.93 (0.75; 1.11)†

0.78 (0.66; 0.90)†

0.73 (0.56; 0.89)