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Table 9 Relative changes from baseline in PRC, Ang II, Aldo, ANP, BNP, and AVP in response to a hypertonic saline infusion (3%, 7 ml kg-1) in 21 patients with essential hypertension and 20 normotensive controls during HS and LS intake

From: Abnormal increase in urinary aquaporin-2 excretion in response to hypertonic saline in essential hypertension

  

60 Min

120 Min

180 Min

PGLM RM

ΔPRC (%)

HS

Patients

-16.1 (-24.5; -7.7)

-16.3 (-37.4; 4.8)

-14.9 (-25.9; -3.9)

P = 0.487

 

Controls

-9.2 (-29.4; 11.0)

-5.1 (-39.8; 29.5)

-7.4 (-40.4; 25.7)

 

LS

Patients

-21.4 (-35.9; -6.8)

-35.2 (-53.7; -16.6)

-29.3 (-50.6; -8.0)

P = 0.526

 

Controls

-30.2 (-49.4; -10.9)

-36.1 (-55.2; -16.9)

-39.0 (-57.8; -20.3)

 

ΔAngII (%)

HS

Patients

-16.4 (-30.3; -2.6)

-12.0 (-30.4; 6.4)§

-15.4 (-27.3; -3.5)§

P = 0.366

 

Controls

-25.0 (-37.2; -12.8)

-14.3 (-33.1; 4.4)

-26.2 (-36.6; -15.8)§

 

LS

Patients

-33.5 (-48.0; -18.9)

-34.7 (-50.1; -19.3)

-38.5 (-50.7; -26.2)

P = 0.845

 

Controls

-36.8 (-48.1; -25.4)

-32.3 (-56.4; -8.2)

-45.1 (-52.3; -37.8)

 

ΔAldo (%)

HS

Patients

-21.7 (-28.7; -14.8)§

-24.3 (-30.6; -18.0)§

-20.1 (-26.5; -13.7)

P = 0.654

 

Controls

-21.5 (-27.0; -15.9)§

-23.7 (-31.8; -15.6)§

-14.9 (-25.9; -4.0)§

 

LS

Patients

-30.2 (-35.1; -25.4)

-34.8 (-40.8; -28.8)

-27.5 (-36.3; -18.7)

P = 0.128

 

Controls

-33.5 (-38.0; -28.9)

-39.2 (-45.5; -32.9)

-36.8 (-43.9; -29.6)

 

ΔANP (%)

HS

Patients

38.6 (24.3; 53.0)

25.6 (13.2; 38.0)

10.9 (-1.0; 22.7)§

P = 0.319

 

Controls

30.6 (16.3; 45.0)§

17.8 (8.3; 27.4)§

6.2 (-3.6; 16.1)§

 

LS

Patients

60.3 (30.9; 89.7)

48.3 (18.5; 78.1)

28.2 (11.3; 45.1)

P = 0.481

 

Controls

48.9 (33.4; 64.4)

35.0 (22.6; 47.4)

25.8 (15.5; 36.1)

 

ΔBNP (%)

HS

Patients

34.6 (-13.9; 83.1)

15.6 (9.4; 21.8)

22.0 (12.3; 31.8)

P = 0.903

 

Controls

15.7 (0.8; 30.6)

22.0 (6.6; 37.4)

26.3 (7.1; 45.6)

 

LS

Patients

15.7 (0.8; 30.6)

22.0 (6.6; 37.4)

26.3 (7.1; 45.6)

P = 0.305

 

Controls

7.8 (0.9; 14.6)

14.9 (4.3; 25.6)

15.2 (5.1; 25.3)

 

ΔAVP (%)

HS

Patients

57.5 (40.9; 74.1)

28.3 (15.9; 40.6)

3.2 (-5.7; 12.1)

P = 0.666

 

Controls

50.9 (31.8; 69.9)

19.0 (6.7; 31.2)

8.4 (-0.7; 17.5)

 

LS

Patients

64.4 (38.6; 90.2)

36.1 (20.5; 51.6)

15.3 (4.5; 26.2)

P = 0.110

 

Controls

41.5 (23.0; 59.9)

20.6 (8.1; 33.1)

9.7 (-4.9; 24.4)

 
  1. PRC, plasma renin concentration; Ang II, angiotensin II, Aldo, aldosterone; ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; AVP, vasopressin. Values are means (95% confidence intervals). PGLM RM: HS compared with LS, GLM Repeated Measures with time as within-subject factor and blood pressure as between-subject factor. * P < 0.05, patients vs. controls, Students t-test. § P < 0.05, HS compared with LS, paired samples t-test
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