Figure 3

Effect of T-5224 on serum BUN and Cr levels after LPS injection. LPS induced serum BUN and Cr levels. a, BUN in the T-5224 group was significantly lower than that in the LPS group at both 24 h and 48 h (24 h, 65.5 ± 13.8 mg/dl vs. 100 ± 15.5 mg/dl; 48 h, 79.8 ± 41.9 mg/dl vs. 180.7 ± 37.4 mg/dl). b, T-5224 also attenuated the increase of serum Cr induced in LPS group (24 h, 0.13 ± 0.04 mg/dl vs. 0.21 ± 0.10 mg/dl; 48 h, 0.32 ± 0.23 mg/dl vs. 0.93 ± 0.11 mg/dl) (n = 6–12 per group). *P < 0.05 vs. control group. **P < 0.01 vs. control group. #P < 0.05 vs. LPS group. ##P < 0.01 vs. LPS group.