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Table 4 Correlations between pathological features and outcomes

From: Validation of the Oxford classification of IgA nephropathy for pediatric patients from China

  HR (95% CI) Univariate P-value HR (95% CI) Multivariateb P-value
Mesangial hypercellularity score (M)
≤0.5 1.0 0.1 1.0 0.6
>0.5 2.1 (0.84-5.1) 1.3 (0.49-3.4)
Endocapillary proliferation (E)
Absent 1.0 0.5 1.0 0.2
Present 0.67 (0.2-2.3) 0.44 (0.12-1.5)
Segmental glomerulosclerosis or adhesion (S)
Absent 1.0 0.03 1.0 0.1
Present 9.2 (1.2-68.6) 5.2 (0.6-43)
Tubular atrophy / interstitial fibrosis (T)
T0 1.0 0.01 1.0 0.04
T1 or T2 4.3 (1.8-10.5) 2.9 (1.0-7.9)
Crescent (C)
Absent 1.0 0.2   NS
Present 1.8 (0.8-4.1)  
  1. Abbreviations: CI, confidence interval; OR, odds ratio; HR, hazard ratio. NS, not significant.
  2. bMultivariate Cox regression model: multivariate with four pathological features (M,E,S,T) + initial eGFR, MAP and proteinuria.