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Table 2 Inflammation markers in serum of patients before treatment initiation with paricalcitol and after 12 weeks of treatment

From: Paricalcitol reduces oxidative stress and inflammation in hemodialysis patients

  

Paricalcitol

 

P value

 

n

Baseline values

After 12 weeks

  

CRP, mg/L

19

21.7 ± 20.7

11.8 ± 10.3

↓

0.0076

TNF-α, pg/mL

13

6.15 ± 3.49

3.23 ± 1.96

↓

0.012

IL-6, pg/mL

13

8.96 ± 3.84

6.23 ± 1.91

↓

0.019

IL-18, pg/mL

13

276 ± 77

199 ± 98

↓

0.028

IL-10, pg/mL

13

0.39 ± 0.03

0.428 ± 0.032

↑

0.019

IDO*, μM Kyn

19

3.33 ± 1.03

3.01 ± 1.14

 

0.167

  1. CRP, C-reactive protein; TNF-α, Tumor necrosis factor; IL-6, Interleukin 6; IL-18, Interleukin 18; IL-10, Interleukin 10; IDO, Indoleamine 2,3-dioxygenase, measured as kynurenine. Values are given as mean ± SD. Statistical significance assessed using Wilcoxon Signed Rank Test.
  2. *IDO: intra-assay coefficient of variation = 2.8%, inter-assay coefficient of variation = 4.8%.
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BMC Nephrology

ISSN: 1471-2369

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