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Table 1 Characteristics of all patients with ESKD secondary to HUS or other causes in Australia and New Zealand 1963–2010, before and after matching for age, gender and RRT era

From: End-stage kidney disease due to haemolytic uraemic syndrome – outcomes in 241 consecutive ANZDATA registry cases

 

Before matching

After matching

Characteristic

HUS ESKD (n = 241)

Other ESKD (n = 58181)

P value

Other ESKD Control (n = 241)

P value

Age

33.1 ± 21.8

54.2 ± 17.3

<0.001

33.1 ± 21.7

1.00

Age category

  

<0.001

 

1.00

0-9 years

43 (18%)

529 (1%)

 

43 (18%)

 

  10-19 years

28 (12%)

1607 (3%)

 

28 (12%)

 

20-29 years

46 (19%)

3978 (7%)

 

46 (19%)

 

30-39 years

32 (13%)

5772 (10%)

 

32 (13%)

 

40-49 years

31 (13%)

9122 (16%)

 

31 (13%)

 

50-59 years

25 (10%)

12339 (21%)

 

25 (10%)

 

60-69 years

21 (9%)

12866 (22%)

 

21 (9%)

 

70-79 years

13 (5%)

9741 (17%)

 

13 (5%)

 

80+ years

2 (1%)

2327 (4%)

 

2 (1%)

 

Male gender

90 (37%)

33913 (58%)

<0.001

90 (37%)

1.00

Racial origin

  

<0.001

 

<0.001

  European

217 (90%)

45368 (78%)

 

170 (71%)

 

  ATSI

4 (2%)

3484 (6%)

 

22 (9%)

 

  MPI

8 (3%)

5106 (9%)

 

24 (10%)

 

  Asian

6 (3%)

2478 (4%)

 

9 (4%)

 

  Other

6 (3%)

1745 (3%)

 

16 (7%)

 

RRT era

  

0.17

 

1.00

 1963-1975

13 (5%)

2821 (5%)

 

12 (5%)

 

 1976-1985

36 (15%)

6505 (11%)

 

36 (15%)

 

 1986-1995

44 (18%)

12119 (21%)

 

45 (19%)

 

 1996-2000

50 (21%)

9811 (17%)

 

49 (20%)

 

 2001-2005

44 (18%)

12357 (21%)

 

45 (19%)

 

 2006-2010

54 (22%)

14568 (25%)

 

54 (22%)

 

Ever smoked

  

<0.001

 

0.85

Current

28 (12%)

6138 (11%)

 

31 (13%)

 

Former

42 (17%)

17713 (30%)

 

48 (20%)

 

Never

130 (54%)

22398 (39%)

 

122 (51%)

 

Missing

41 (17%)

11932 (21%)

 

40 (17%)

 

Hypertension

  

<0.001

 

0.98

 Yes

89 (37%)

24464 (42%)

 

87 (36%)

 

 No

37 (15%)

4519 (8%)

 

38 (16%)

 

 Missing

115 (48%)

29198 (50%)

 

116 (48%)

 

Diabetes mellitus

  

<0.001

 

<0.001

  Yes

8 (3%)

17874 (31%)

 

51 (21%)

 

  No

201 (83%)

31796 (55%)

 

163 (68%)

 

  Missing

32 (13%)

8511 (15%)

 

27 (11%)

 

Chronic lung disease

  

0.009

 

0.47

  Yes

16 (7%)

7139 (12%)

 

22 (9%)

 

  No

190 (79%)

41125 (71%)

 

190 (79%)

 

  Missing

35 (15%)

9917 (17%)

 

29 (12%)

 

Coronary artery disease

  

<0.001

 

0.13

  Yes

22 (9%)

17613(30%)

 

36 (15%)

 

  No

184 (76%)

30768 (53%)

 

176 (7%)

 

  Missing

35 (15%)

9800 (17%)

 

29 (12%)

 

Peripheral vascular disease

  

<0.001

 

0.04

  Yes

15 (6%)

11440 (20%)

 

31 (13%)

 

  No

191 (79%)

36823 (63%)

 

181 (75%)

 

  Missing

35 (15%)

9918 (17%)

 

29 (12%)

 

Cerebrovascular disease

  

0.01

 

0.38

  Yes

14 (6%)

6540 (11%)

 

9 (4%)

 

  No

192 (80%)

41742 (72%)

 

204 (84%)

 

  Missing

35 (15%)

9899 (17%)

 

29 (12%)

 

BMI (kg/m2)

22.7 ± 6.2

26.6 ± 6.3

<0.001

24.5 ± 7.7

0.02

Late referral

  

<0.001

 

<0.001

  Yes

88 (37%)

9304 (16%)

 

34 (14%)

 

  No

86 (36%)

33773 (58%)

 

156 (65%)

 

  Missing

67 (28%)

15104 (26%)

 

51 (21%)

 

Renal Biopsy

  

<0.001

 

<0.001

  Yes

89 (37%)

16019 (28%)

 

85 (35%)

 

  No

61 (25%)

29135 (50%)

 

117 (49%)

 

  Miss

91 (38%)

13027 (22%)

 

39 (16%)

 

First RRT

  

0.46

 

0.02

  Haemodialysis

163 (68%)

39135 (67%)

 

134 (56%)

 

  Peritoneal dialysis

69 (29%)

17570 (30%)

 

92 (38%)

 

  Renal Transplant

9 (4%)

1476 (3%)

 

15 (6%)

 

RRT duration (years)

4.7 [1.6-11.8]

3.8 [1.6-8.3]

0.03

6.4 [2.3-14.3]

0.03

  1. Abbreviations: ATSI Aboriginal and Torres Strait Islander, BMI Body mass index, MPI Maori and Pacific Islander, RRT Renal replacement therapy.