Figure 1From: Disruption of the endothelin A receptor in the nephron causes mild fluid volume expansion Schema of conditional KO of the ENDRA gene. The Pax8 promoter drives expression of rtTA which requires doxycycline to activate the bicistronic Cre recombinase and luciferase-expressing transgene. Cre is expressed specifically in the nephron but not in glomeruli. ETA receptor KO mice are homozygous for the floxed ENDRA gene and heterozygous for the two transgenes.Back to article page