Figure 4
From: Disruption of the endothelin A receptor in the nephron causes mild fluid volume expansion
Systolic (Panel A) and diastolic (Panel B) BP in control and Pax8-rtTA/LC1/floxed ETA (iETA) mice before and after doxycycline (DOX) treatment. Animals were fed a normal (0.3%) Na diet for 3 days followed by a high (3.2%) Na diet for 5–7 days. DOX was given for 11 days, then BP recordings continued 5 days after discontinuation of DOX. BP was obtained by continuous radiotelemetry. Daily BP values are shown as the average of the every 10-minute recordings throughout that 24 hr period. N = 12 each data point.