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Table 4 Mean eGFRs and CKD prevalence for IL4T-33C and IL6C-572G genotypes

From: Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study

Genotype

n

eGFR (ml/min/1.73 m2)

 

CKD (eGFR < 60 ml/min/1.73 m2)

   

mean ± SD

β†

(95% CI)

P-value†

 

n

(%)

OR†

(95% CI)

P-value†

IL4 T-33C

            
 

TT

1,452

73.4 ± 14.6

0

(reference)

-

 

259

(17.8%)

1

(reference)

-

 

TC

1,466

74.4 ± 15.1

0.9

(-1.2-2.9)

0.346

 

241

(16.4%)

0.91

(0.78-1.07)

0.269

 

CC

403

75.7 ± 14.5

2.2

(-1.9-6.3)

0.240

 

46

(11.4%)

0.59

(0.37-0.95)

0.029

IL6 C-572G

            
 

CC

1,911

74.2 ± 14.7

0

(reference)

-

 

312

(16.3%)

1

(reference)

-

 

CG

1,185

73.4 ± 14.8

-1.1

(-2.3-0.1)

0.065

 

208

(17.6%)

1.13

(0.98-1.31)

0.091

 

GG

225

76.9 ± 15.9

2.6

(-0.1-5.2)

0.055

 

26

(11.6%)

0.67

(0.50-0.90)

0.008

  1. †adjusted for age, sex, hypertension, diabetes mellitus, and cardiovascular diseases. Standard errors were adjusted for study areas. eGFR = estimated glomerular filtration rate. CKD = chronic kidney disease. CKD is defined by eGFR < 60 ml/min/1.73 m2.